Cas No.: | |
Chemical Name: | ibap |
Synonyms: | I-BAP |
Formula: | C18H16N2O2 |
M.Wt: | 292.12 |
Purity: | >97% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Publication: | Lu Wang et al, Epigenetic targeted therapy of stabilized BAP1 in ASXL1 gain-of-function mutated leukemia, Nature Cancer (2021). DOI: 10.1038/s43018-021-00199-4 |
Description: | iBAP (BAP1 inhibitor I) is a first-in-class inhibitor of the catalytic activity of BAP1 histone H2A deubiquitinase complex with IC50 of 0.5-1 uM in vitro, |