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S-BAY-8040

  Cat. No.:  DC39256   Featured
Chemical Structure
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More than 5000 active chemicals with high quality for research!
Field of application
S isomer of BAY-8040.Bay-8040 is a potent, selective human neutrophil elastase (HNE) inhibitor with IC50 of 28 nM; displays no significant inhibition toward 68 other pharmacologically relevant targets (>10 uM), and a panel of related serine proteases; shows in vivo efficacy with regard to decreasing cardiac remodeling and amelioration of cardiac function in monocrotaline-induced rat model for pulmonary arterial hypertension.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.:
Chemical Name: Benzonitrile, 4-​[(4S)​-​1,​2,​3,​4,​5,​6,​7,​8-​octahydro-​7-​methyl-​2,​5-​dioxo-​1-​[3-​(trifluoromethyl)​phenyl]​pyrimido[4,​5-​d]​pyridazin-​4-​yl]​-
Synonyms: S-BAY-8040;S-BAY 8040;S-BAY8040
SMILES: C(C1C=CC([C@H]2NC(=O)N(C3C=C(C(F)(F)F)C=CC=3)C3=C2C(NN(C3)C)=O)=CC=1)#N
Formula: C21H16F3N5O2
M.Wt: 427.38
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. von Nussbaum F, et al. ChemMedChem. 2016 Jan 19;11(2):199-206.
MSDS
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COA
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Cat. No. Product name Field of application
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