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Sirtuin modulator 2

  Cat. No.:  DC71745   Featured
Chemical Structure
667910-69-2
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More than 5000 active chemicals with high quality for research!
Field of application
Sirtuin modulator 2 (Compound 132) is a sirtuin modulator with an ED50 equal or less than 50 μM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 667910-69-2
Chemical Name: Sirtuin modulator 2
Synonyms: BENZAMIDE, N-(3-IMIDAZO[2,1-B]THIAZOL-6-YLPHENYL)-2-METHOXY-;Benzamide, N-(3-imidazo[2,1-b]thiazol-6-ylphenyl)-2-methoxy-;N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide;Sirtuin modulator 2
SMILES: S1C=CN2C=C(C3C=CC=C(NC(=O)C4=CC=CC=C4OC)C=3)N=C12
Formula: C19H15N3O2S
M.Wt: 349.406
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC71745 Sirtuin modulator 2 Sirtuin modulator 2 (Compound 132) is a sirtuin modulator with an ED50 equal or less than 50 μM.
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DC70359 DK1-04e DK1-04e serves as a prodrug for the potent SIRT5 inhibitor DK1-04 (IC50 = 340 nM), demonstrating significant anti-tumor activity in breast cancer models. The compound effectively suppresses mammary tumor progression in both MMTV-PyMT transgenic mice and human xenograft models, with cellular studies confirming SIRT5 inhibition disrupts cancer cell proliferation and transformation.
DC40849 SIRT1-IN-1 SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity.
DC40782 SIRT7 inhibitor 97491 SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway..
DC11213 E1231 E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM, interactes with recombinant human SIRT1 protein and deacetylated liver X receptor-alpha (LXRα).
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