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| Cas No.: | 2305936-56-3 |
| Chemical Name: | TD-165 |
| Synonyms: | TD-165;(2S,4R)-1-[(2S)-2-[11-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]undecanoylamino]-3, |
| SMILES: | S1C([H])=NC(C([H])([H])[H])=C1C1C([H])=C([H])C(=C([H])C=1[H])C([H])([H])N([H])C([C@]1([H])C([H])([H])[C@]([H])(C([H])([H])N1C([C@]([H])(C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])N([H])C(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C1=C([H])C([H])=C([H])C2C(N(C(C=21)=O)C1([H])C(N([H])C(C([H])([H])C1([H])[H])=O)=O)=O)=O)=O)O[H])=O |
| Formula: | C46H59N7O8S |
| M.Wt: | 870.0678 |
| Purity: | >98% |
| Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
| Publication: | [1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654. [Content Brief] |
| Description: | TD-165 is a PROTAC-based cereblon (CRBN) degrader that degrads Cav1.2α with the DC50 of 20.4 nM, comprising a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. |
| References: | [1]. Kim K, et al. Disordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera.Sci Rep. 2019 Dec 23;9(1):19654. [Content Brief] |
MSDS
| TITLE | DOWNLOAD |
| MSDS_32335_DC48434_2305936-56-3 |
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COA
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