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Home > PROTACs > E3 Ligase Ligand

Thalidomide-5,6-F

  Cat. No.:  DC47216   Featured
Chemical Structure
1496997-41-1
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Field of application
Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1496997-41-1
Chemical Name: 2-(2,6-Dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione
Synonyms: Thalidomide-5,6-F;2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindoline-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5,6-difluoro-2,3-dihydro-1H-isoindole-1,3-dione;2-(2,6-dioxopiperidin-3-yl)-5,6-difluoroisoindole-1,3-dione;ZB1849;AT17986;SY289994
SMILES: FC1=C(C([H])=C2C(=C1[H])C(N(C2=O)C1([H])C(N([H])C(C([H])([H])C1([H])[H])=O)=O)=O)F
Formula: C13H8F2N2O4
M.Wt: 294.2104
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC86101 VH032-cyclopropane-F E3 ligase Ligand 19 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 19 can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1]
DC51007 Lenalidomide-5-aminomethyl hydrochloride Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
DC51006 Lenalidomide-4-OH A Novel PROTACs building block.
DC71103 Pomalidomide-PEG4-COOH Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1).
DC47216 Thalidomide-5,6-F Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
DC41134 Thalidomide-5-OH Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
DC12028 MDK7526(Protein degrader 1) MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.
DC11571 E3 Ligase Ligand 3 E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.
DC50061 Pomalidomide-C2-NH2(E3 ligase Ligand 17) E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
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