Dimethadione is an anticonvulsant that is the active metabolite of trimethadione.

Dimebon is an antihistamine drug.

DIMATE is a novel irreversible, competitive, isoform-specific ALDH1 inhibitor, displays cytotoxic activity on human AML cell lines with IC50 of 1-15 uM.

Dihydromunduletone is a rotenoid derivative that selectively inhibits GPR56 (IC50=21 uM) and GPR114/ADGRG5, but not GPR110 or Class A GPCRs.

Dihydroisotanshinone I is a bioactive compound present in a widely used traditional Chinese medicine named danshen.

Diflunisal is a difluorophenyl derivate of salicylic acid and a nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic and anti-inflammatory properties. The mechanism of action of diflunisal is as a Cyclooxygenase Inhibitor.

Diethyl-pythiDC is an inhibitor of collagen prolyl 4-hydroxylases (CP4Hs).

Diethylmaleate is the diethyl ester of maleic acid and a glutathione-depleting compound that inhibits NFkB.

Didemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine.

Didanosine(Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM. Target: NRTIs; HIV Didanosine is a dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by a hydrogen.

Dicycloplatin (DCP) is a novel platinum analog that demonstrates significant antitumor activity against a variety of human cancer cell lines with IC50 of 25-30 nM.

Diazoxide is a well-known small molecule that activates KATP channels in the smooth muscle of blood vessels and pancreatic beta-cells by increasing membrane permeability to potassium ions.

Diazepinomicin (TLN 4601.

Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor.

DI-591 (DI591) is a potent, selective, cell-permeable inhibitor of the DCN1-UBC12 interaction with Ki of 10-12 nM for human DCN1 and DCN2.

DI-404 is a highly potent, peptidomimetic inhibitor of DCN1-UBC12 protein-protein interaction that bind to DCN1 protein with Kd of 6.9 nM, selectively inhibits the neddylation of cullin 3 over other cullin members.

D-I03 (D-103) is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5 uM, binds to RAD52 with Kd of 25.8 uM and inhibits D-loop formation with IC50 of 8 uM in vitro.

DH-376 is a highly potent dual DAGLα/β inhibitor with IC50 of 6 nM and 3-8 nM, respectively.

DGAT2 inhibitor 2 is a novel potent, selective DGAT2 inhibitor with IC50 of 6 nM (hDGAT2), shows no significant activity for DGAT1 (IC50>20 uM).

DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM..

DGAT-1 inhibitor 2 is an effective inhibitor of DGAT-1;antiobesity agents.

D-G23 is a small molecule that inhibits RAD52-mediated ssDNA annealing with IC50 of 5.8 uM, binds to RAD52 with Kd of 34 uM and inhibits D-loop formation with IC50 of 7.2 uM in vitro.

DFMO (Ornithine Decarboxylase inhibitor DFMO) is an irreversible inhibitor of ornithine decarboxylase (ODC), inhibits polyamine biosynthesis.

D-Fagomine (Fagomine) is a a mild glycosidase inhibitor, inhibits Amyloglucosidase (A.niger), β-Glucosidase (bovine), and Isomaltase (yeast) with Ki of 4.8 uM, 39 uM, and 70 uM, respectively.

Dexpanthenol is an alcoholic analogue of D-pantothenic acid and cholinergic agent.

Detomidine hydrochloride produce dose-dependent sedative and analgesic effects, is a nonnarcotic, synthetic α2-adrenergic agonist

Desvenlafaxine succinate hydrate is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI).

Desoximetasone is a glucocorticoid.

Deracoxib, a selective cyclooxygenase-2 inhibitor, is a non-narcotic, non-steroidal anti-inflammatory drug (NSAID).

Deoxyspergualin is a derivative of the antitumor antibiotic spergualin that binds specifically to Hsc70, also inhibits poly(rC) binding protein 2 (PCBP2)..