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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC10308 Deoxycytidine triphosphate
Deoxycytidine triphosphate (dCTP), a nucleoside triphosphate, is a raw material in DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
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DC7199 Denibulin (MN-029)
Denibulin (MN-029) is a novel vascular-disrupting agent that reversibly inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor vascular endothelial cells.
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DC10850 Dencichine
Dencichin is a non-protein amino acid originally extracted from Panax notoginseng, and can inhibit HIF-prolyl hydroxylase-2 (PHD-2) activity.
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DC20949 Deltazinone 1
Deltazinone 1 (Deltazinone1) is a novel highly selective PDEδ inhibitor that inhibits PDEδ/Ras interaction with Kd of 8±4 nM.
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DC20948 Deltasonamide 2
Deltasonamide 2 (Deltasonamide-2) is a novel small molecule inhibitor of PDE6δ/KRas interaction with Kd of 385 pM.
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DC20772 Deleobuvir
Deleobuvir (BI-207127, BI207127) is a potent, selective HCV NS5B polymerase inhibitor with IC50 of 50 nM against GT-1 HCV polymerase activity.
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DC8897 Delavirdine
Delavirdine(U 90152) is a potent non-nucleoside reverse transcriptase inhibitor (NNRTI).
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DC11352 Delavirdine (mesylate)
Delavirdine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that selectively inhibits HIV-1 reverse transcriptase over DNA polymerase α and δ in vitro (IC50s = 0.26, 440, and >550 μM, respectively).
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DC12073 Dehydronitrosonisoldipine
Dehydronitrosonisoldipine is a calcium channel antagonist.
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DC23727 Dehydromutactin
Dehydromutactin is a small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 40 nM.
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DC10111 Debio 0617B
Debio 0617B has been developed as a first-in-class kinase inhibitor with a unique profile targeting phospho-STAT3 (pSTAT3) and/or pSTAT5 in tumors through combined inhibition of JAK, SRC, ABL, and class III/V receptor tyrosine kinases (RTK).
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DC12560 DDR-TRK-1
DDR-TRK-1 (DDR1 inhibitor 6j) is a potent, selective selective DDR1 inhibitor with IC50 of 9.4 nM, also potently inhibits TRK family with IC50 of 18-100 nM.
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DC23857 DDR2-IN-5
DDR2-IN-5 is a potent, dual DDR2/SRC inhibitor with IC50 of 56/12 nM, potently suppresses DDR2 mutated cell lines HCC-366 and NCI-H2286 with IC50 of 0.44 uM and 0.29 uM..
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DC23844 DDR1 inhibitor 7rh
DDR1 inhibitor 7rh is a potent, selective, ATP-competitive, orally available Discoidin domain receptor 1 (DDR1) inhibitor with IC50 of 6.8 nM in cell-free kinase assays.
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DC12521 DDR1 inhibitor 2.45
DDR1 inhibitor 2.45 (Compound 2.45) is a novel potent, selective, bioavailable Discoidin Domain Receptor 1 (DDR1) inhibitor with IC50 of 29 nM, displays 64-fold selectivity over DDR2 in biochemical assays.
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DC10413 DDP-38003 dihydrochloride
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.
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DC12593 DD-03-171
DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3.
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DC24137 DCVC
DCVC (S-(1,2-dichlorovinyl)-L-cysteine) is an active metabolite of trichloroethylene.
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DC12055 DC1-SMe
DC1-Sme is an antibody conjugate of phosphate prodrug of cytotoxic DNA alkylators for the targeted treatment of cancer.
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DC12361 DC1
DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.
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DC23976 DC_517
DC_05 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases.
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DC8108 DBPR108
DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. IC50 value: 15 Nm.
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DC21892 dBET23
dBET23 is a BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays..
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DC21987 DBCO-PEG4 amine
DBCO-PEG4 amine (ADIBO-PEG4-amine) is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC22076 DBCO-NHS ester 3
DBCO-NHS ester 3 (DIBAC-NHS) is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC20355 DBCO-NHS ester 2
DBCO-NHS ester 2 is a derivative of DBCO (Dibenzylcyclooctyne) used in Cu-free click chemistry.
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DC21891 DBCO Maleimide
DBCO Maleimide is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21889 DBCO intermidate 2
DBCO intermidate 2 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21888 DBCO intermidate 1
DBCO intermidate 1 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21886 DBCO acid 5
DBCO acid 5 is a Click Chemistry intermidate used for antibody-drug conjugates..
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