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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC21885 DBCO acid 4
DBCO acid 4 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21884 DBCO acid 3
DBCO acid 3 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21883 DBCO acid 2
DBCO acid 2 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21882 DBCO acid 1
DBCO acid 1 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC12517 HT105
DB550 (DB-550, TCWKHRK) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM.
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DC12516 DB550
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM.
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DC20943 DB2115
DB2115 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM.
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DC22067 DB1055
DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.
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DC20942 DB04760
DB04760 is a potent, highly selective, non–zinc-chelating MMP-13 inhibitor with IC50 of 8 nM, displays high selectivity over other MMPs.
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DC9331 Daun02
Daun02 is a daunorubicin b-galactoside prodrug for use in conjunction.
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DC21381 Dasolampanel
Dasolampanel (NGX426) is an orally bioavailable, competitive antagonist of the AMPA-kainate receptors for the treatment of chronic pain conditions including neuropathic pain and migraine..
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DC3152 Darifenacin
Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
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DC10259 Dapson
Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.
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DC20354 DAPH-12
DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).
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DC8665 Dantrolene sodium hemiheptahydrate
Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene sodium hemiheptahydrate is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ fro
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DC12338 Dansylamide
Dansyl amide is a fluorescent dye that is used in biochemistry and chemistry to label substances with the fluorescent dansyl group.
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DC22810 Damnacanthal
Damnacanthal is a highly potent, selective inhibitor of p56 lck tyrosine kinase with IC50 of 17 nM for inhibition of p56lck autophosphorylation.
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DC21469 Dagrocorat
Dagrocorat (PF 00251802) is a potent, selective high-affinity dissociated agonist of the glucocorticoid receptor..
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DC11232 D715-2441
D715-2441 (D 715-2441) is a novel antiviral compound that interferes with the conserved cap-binding domain of the PB2 protein, exhibits potent antiviral activity against influenza A viruses (IAVs) with IC50 of 1.7-4.4 uM.
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DC11124 D-520
D-520 is a potent, multifunctional D2/D3 agonist with Ki of 41.8 /0.35 nM, modulates aggregation of alpha-synuclein (αSN) and reduces toxicity of preformed aggregates of αSN.
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DC12610 D159153
D159153 (D-159153) is a novel potent, allosteric inhibitor of PDE4 with cellular IC50 of 28.5 and 6.6 nM for PDE4B1 and PDE4D3, respectively..
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DC25001 D-156844
D156844 is a potent SMN2 inducer and DcpS inhibitor.
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DC12582 D13-9001
D13-9001 (D 13-9001) is a small molecule, MexAB-OprM specific efflux pump inhibitor with good potency in vitro (MPC 2 ug/mL) and displays excellent activity in vivo in a rat pneumonia model of P. aeruginosa..
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DC9886 D-(+)-Cellobiose
D-(+)-Cellobiose is a substrate of β-glucosidase.
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DC11198 CZh226 hydrochloride
CZh226 hydrochloride (CZh-226) is a potent, selective inhibitor of p21-activated kinase 4 (PAK4) with Ki of 9 nM, displays 346-fold selectivity over PAK-1.
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DC5134 lexibulin (CYT997)
CYT997 is a potent microtubule polymerization inhibitor with IC50 of 10-100 nM in cancer cell lines. Phase 1/2.
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DC20352 CYP11B1-IN-25
CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2.
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DC12470 CYH33 methanesulfonate
CYH33 (CYH-33) is a novel potent, PI3Kα-selective inhibitor with IC50 of 5.9 nM/598 nM/ 78.7 nM/225 nM aginst class I PI3K isoform α/β/δ/γ, respectively.
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DC23283 CYD-2-11
CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM).
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DC20351 CYD-1-79
CYD-1-79 is a potent, selective 5-HT2C receptor positive allosteric modulator (PAM), potentiates 5-HT-evoked intracellular calcium release in cells stably expressing the human 5-HT2CR but not the 5-HT2AR cells..
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