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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC11740 GB-88
GB-88 is a selective, orally available PAR2 antagonist that inhibits PAR2 activated Ca(2+) release with IC50 of 2 uM.
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DC21040 GB-83
GB-83 is a selective, reversible PAR2 (Protease-activated receptor 2) antagonist with IC50 of 2 uM.
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DC11741 GB-110
GB-110 is a potent, non-peptidic agonist of PAR2 that selectively induces PAR2-mediated intracellular Ca(2+) release in HT29 cells with EC50 of 0.28 uM.
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DC11119 GAT-211
GAT-211 (GAT211) is a selective cannabinoid 1 receptor (CB1R) positive allosteric modulator with pKb of 7.26, Arrestin2 EC50 of 775 nM.
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DC11122 GAT-100
GAT-100 (GAT100) is a potent, selective CB1R negative allosteric modulator (NAM) with cAMP EC50 and β-arr EC50 of 174 nM and 2.1 nM, does not exhibit inverse agonism.
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DC8893 Garenoxacin Mesylate hydrate
Garenoxacin mesylate hydrate is a novel oral des-fluoro(6) quinolone with potent antimicrobial activity, against common respiratory pathogens, including resistant strains.
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DC8929 Garenoxacin
Garenoxacin is a quinolone antibiotic for the treatment of Gram-positive and Gram-negative bacterial infections.
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DC23398 Garcinol
Garcinol (Camboginol) is a potent, natural inhibitor of histone acetyltransferases (HATs) p300 (IC50=7 uM) and PCAF (IC50=5 uM) both in vitro and in vivo.
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DC9453 GANT 58
GANT 58 is a novel and potent Gli antagonist that inhibits GLI1-induced transcription (IC50 = 5 uM).
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DC9640 gamma-secretase modulator 3
gamma-secretase modulator 3 is a gamma-secretase modulator.
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DC12090 Gamitrinib TPP
Gamitrinib TPP is a GA mitochondrial matrix inhibitor.
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DC11071 Gambogenic acid
Gambogenic acid (GNA) is a polyprenylated xanthone isolated from gamboge, shows potent antitumor activity and can effectively inhibit the survival and proliferation of cancer cells.
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DC12305 Galactose 1-phosphate Potassium salt
Galactose 1-phosphate Potassium salt is is an intermediate in the galactose metabolism and nucleotide sugars
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DC12228 Galactose 1-phosphate
Galactose 1-phosphate is an intermediate in the galactose metabolism and nucleotide sugars.
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DC9381 Gabapentin (hydrochloride)
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog.
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DC21036 E-72
G9a inhibitor E72 (E-72) is a potent inhibitor of histone H3K9 methyltransferases G9a and G9a-like protein (GLP) with Kd of 136 nM and 164 nM, shows selectivity over the related H3K9 methyltransferase Suv39H2.
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DC21035 G907
G907 is a potent, selective small-molecule antagonist of ATP-binding cassette (ABC) transporter MsbA with IC50 of 18 nM.
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DC11776 G-744
G-744 is a highly potent, selective inhibitor of BTK with biochemical Ki of 1.28 nM.
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DC22548 G-5555
G-5555 is a potent and selective PAK1 inhibitor (Ki=3.7 nM).
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DC11449 G0775
G0775 is a Synethetic analogs of arylomycins.
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DC21034 G 573
G 573 is a potent and selective, allosteric inhibitor of MEK with Ki of 0.3 nM.
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DC21032 G 0507
G 0507 is a novel inhibitor of the bacterial LolCDE ABC transporter, binds to LolCDE and stimulates its ATPase activity.
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DC21031 FzM1.8
FzM1.8 is a small molecule, allosteric agonist of the Frizzled receptor Fzd4 with pEC50 of 6.4, potentiates β-catenin pathway in the absence of any WNT ligand.
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DC21792 FV-100
FV-100 (Valnivudine, CF-1743) is a potent, selective, bicyclic nucleoside analogue inhibitor of varicella zoster virus (VZV) with EC50 of subnanomolar range in vitro..
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DC10240 Fusidate Sodium
Fusidate Sodium is a sodium salt form of fusidic acid, a bacteriostatic antibiotic derived from the fungus Fusidium coccineum and used as a topical medication to treat skin infections.
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DC21027 Fumosorinone
Fumosorinone is a novel potent, selective protein tyrosine phosphatase SHP2 inhibitor with IC50 of 6.31 uM.
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DC12362 Fuchsine base monohydrochloride
Fuchsine base (monohydrochloride) is a magenta dye, which is certified for use for acid-fast staining with carbol-fuchsin.
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DC12537 FtsZ inhibitor C109
FtsZ inhibitor C109 (Compound 10126109) is a broad spectrum antibacterial compound that inhibits the cell division protein FtsZ, inhibits the FtsZ GTPase activity with IC50 of 8.2 uM.
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DC22096 FT895
FT895 (FT-895) is a potent and selective inhibitor of HDAC11 with IC50 of 3 nM, displays no significant activity against HDAC1-10 (IC50>5 uM).
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DC23388 FT-001
FT-001 is a novel potent, orally acitve inhibitor of BET bromodomain with IC50 of 0.1 uM for BRD4 BD1.
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