Novel potent aryl hydrocarbon receptor (AHR) antagonist with the capacity to inhibit both DRE-dependent and -independent activity

Novel selective CHK1 inhibitor

Novel GluN2A-selective NMDA receptor positive allosteric modulator (PAM)

Negative control for GNE-2256

Novel inhibitor of nicotinamide phosphoribosyl transferase (NAMPT)

Novel NMDAR PAM with both an improved pharmacokinetic profile and increased selectivity against AMPARs

Novel GluN2A-selective NMDA receptor positive allosteric modulator (PAM)

Novel Met inhibitor

Novel potent and selective RORc inverse agonist

Novel GluN2A subunit-selective and brain-penetrant positive allosteric modulator (PAM) of The N-methyl-d-aspartate receptor (NMDAR)

Novel Tubulin Polymerization Inhibitor

Negative control for GMB-805

Novel potent BCR-Abl PROTAC, inducing degradation and demonstrating in vivo activity

Selective modulator of gamma-aminobutyric acid(A) receptors

Novel GM3 derivative, showing excellent migration and invasion inhibitory effects in cells and marked antitumor activity in C57BL/6 mice, involving focal adhesion and ECM-receptor interaction signaling pathways

Metabolite of soy isoflavones, promoting the proliferation of bone marrow stromal cells and osteoblasts and suppresses bone turnover

Novel glucose transporter (GLUT) inhibitor, exhibited high antitumor potency through the suppression of glucose uptake (IC 50 : 2.5 μM), while not cytotoxic to prostate and mammary epithelial cells

Glucose transporter inhibitor linker for insulin conjugate

Selective inhibitor of human glucose transporter subtype 1/4 (hGLUT1/4)

Selective inhibitor of human glucose transporter subtype 1/4 (hGLUT1/4)

Novel potent glucose transporter type 4 (GLUT4) translocation activator, showing a significant blood glucose lowering effect in the severe diabetic mice model

Novel inhibitor of glutaminase 1 (GLS1) with high binding affinity (SPR, Kd = 24 nM; ITC, Kd = 37 nM), exhibiting a similar in vivo antitumor activity as CB839

The first-in-class, ATP-competitive inhibitor of MAPKAPK5

Ago-allosteric modulator of human GLP-2R

Enteroendocrine hormone, stimulating the growth of intestinal epithelium

Novel inhibitor of glyoxalase 1 (Glo1), increasing the cellular methylglyoxal levels in human cells and suppressing the osteoclast formation of mouse bone marrow-derived macrophages

Novel potent Glyoxalase 1 (GLO1) inhibitor, demonstrating to penetrate the blood-brain barrier, elevating levels of methylglyoxal in the brain, and reducing depression-like behavior in mice

Novel inhibitor of the acetyltransferase activity of Escherichia coli N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU).

Second-generation sulfonylurea, promoting the accumulation of fructose 2,6-bisphosphate in hepatocytes

Novel Galactofuranosyltransferase 2 (GlfT2) inhibitor