AMG28 is a Tau tubulin kinase 1 (TTBK1) and TTBK2 inhibitor with IC50s of 805 nM and 988 nM, respectively. AMG28 inhibits tau phosphorylation at Ser422 (IC50 of 1.85 μM).

AMCA (4-(Aminomethyl)-1-cyclohexanecarboxylic acid) is a PROTAC linker. AMCA can be used to synthesize the PROTAC molecule YB-3–17.

Alvespimycin (17-DMAG) TFA is a potent inhibitor of Hsp90, binding to Hsp90 with an EC50 of 62 ± 29 nM.

Almoxatone is an orally effective, long-acting inhibitor of MAO-B.

AKV-9 is the inhibitor for mutated Cu/Zn superoxide dismutase (SOD1), that inhibits SOD1-induced protein aggregation and exhibits protective efficacy against SOD1-induced cytotoxicity in PC-12 with an EC50 of 0.3 μM. AKV-9 ameliorates amyotrophic lateral sclerosis in mouse models and extends their lifespan.

AIM4 is a compound that can inhibit the aggregation of TDP-43. AIM4 has good biocompatibility and anti-inflammatory activity. AIM4 can be used in the research of diseases such as amyotrophic lateral sclerosis.

A181 (AI-181) is a DENV-2 inhibitor. A181 can be used for anti-dengue studies.

ADC-5 drug-linker is a drug-linker conjugate for ADC with potent anti-tumor activity. ADC-5 drug-linker can be used to synthesize NLRP3 agonist 3 in the NCI-N87 xenograft mouse model produces a synergistic therapeutic effect.

Aceclofenac ethyl ester is an impurity of Aceclofenac.

ABT-518 is a matrix metalloproteinase inhibitor with anti-tumor activity. ABT-518 has potent inhibitory effects on gelatinase A and gelatinase B, which can inhibit tumor growth and metastasis.

ABCA1 inducer 2 is a non-lipotropic ABCA1 inducer. ABCA1 inducer 2 upregulates the expression of ABCA1 by targeting the LXR pathway. ABCA1 inducer 2 can reduce ox-LDL-induced lipid accumulation and thus inhibit foam cell formation. ABCA1 inducer 2 has anti-atherosclerotic potential.

AA-dUTP tetrasodium is an amine-modified nucleotide that has been used in the synthesis of fluorescently labeled dUTP.

A-39183A is an antibiotic that shows significant cytotoxicity to HeLa cells, with an IC50 value of 1.8 μM.

8-Sulfamoyloctanoic acid is a PROTAC linker that can be used in the synthesis of PROTAC XZ338.

8-prenylchrysin is a C8-prenylated flavonoid. 8-prenylchrysin inhibits P-gp. 8-prenylchrysin can be used for tumor research.

8-BuS-AMP is a CD39 and CD73 dual inhibitor. 8-BuS-AMP inhibits human CD39, mouse CD39 and human CD73 with Kis of 0.292, 2.19 and 1.19 μM, respectively.

7α-Hydroxy-DHEA (7α-Hydroxydehydroepiandrosterone) is a 7α-hydroxylated metabolite of DHEA.

7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo.

7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC50 value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect.

7-Azaspiro[3.5]nonane-piperidine-Boc is a PROTAC linker. 7-Azaspiro[3.5]nonane-piperidine-Boc can be used to synthesize RP03707 in neuroblastoma cells.

6β-Hydroxy dexamethasone is an active metabolite of the synthetic glucocorticoid Dexamethasone.

6α-Hydroxy metandienone is an androgenic anabolic steroid metabolite of Metandienone.

6-Epi-doxycycline is the C-6 epimer of Doxycycline, formed as a degradation impurity through epimerization of Doxycycline under abnormal conditions (e.g., high temperature, pH changes, or humidity). 6-Epi-doxycycline is commonly used for the detection and analysis of impurity levels in pharmaceutical formulations.

6-Chloro-7-deazaguanine (compound 63) is an inactive molecule of IKK (lacking the critical 5-cyano group), targeting IKKα and IKKβ with Ki values both greater than 30 μM. IKKβ and IKKα are core molecules in the canonical and non-canonical NF-κB pathways, respectively.

6-Alkyne-F-araNAD is an irreversible inhibitor of CD38. 6-Alkyne-F-araNAD helps other fluorescent probes (such as SR101−F-araNMN) to more clearly observe the localization of intracellular CD38.

6,2′,4′-Trimethoxyflavone is an AhR antagonist and has failed to show effective protective effects against cerebral ischemia/reperfusion injury in Sprague-Dawley rats.

6-(4-Azidobutanamido) hexanoic acid is a PROTAC Linker that can be used to synthesize the PROTAC molecule NR-11c.

5-OxoETE methyl ester is the agonist for oxoeicosanoid receptor 1 (OXER1). 5-OxoETE methyl ester binds to OXER1, and activates downstream signaling pathways β-arrestin recruitment with an EC50 of 1.54 µM.

5-Oxo leukotriene B4 is a byproduct in the synthesis of 12-oxo LTB4.

5'-Hydroxy meloxicam is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) Meloxicam.