Novel NMDA receptor antagonist

Novel non-toxic fluorescent probe to label the renal proximal tubules in zebrafishReference1) The small molecule probe PT-Yellow labels the renal proximal tubules in zebrafish; Chem Commun (Camb). 2015;51(2):395-8. doi: 10.1039/c4cc08075k. Epub 2014 Nov 1

Novel ligand for the Methyl-lysine Binding Protein, 53BP1.

Novel highly potent BET bromodomain inhibitor with more than 100-fold higher cellular potency than the corresponding monovalent antagonist JQ1

Anti-inflammatory drug

Novel inhibitor of human betaine-homocysteine S-methyltransferase (BHMT)References: 1) Strakova J, Gupta S, Kruger WD, Dilger RN, Tryon K, Li L, Garrow TA. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and redu

Gene-selective LXR modulator that mediates potent transcriptional activation of ABCA1 gene expression while exhibiting minimal effects on SREBP-1c

Full 5-HT1A serotonin receptor agonist; more active enantiomer.

A GABA antagonist that acts via the benzodiazepine binding site of ag containing GABA receptors

Novel activator of the transient receptor potential channel ML3 (TRPML3)

Psychostimulant that displays neuroprotective and antiparkinsonian activity in a primate model of Parkinson's disease

Selective dopamine agonist

Apoptosis inducer with selective antiproliferative activity.

Novel inhibitor of Ral binding to its effector RALBP1 and inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-independent growth of human cancer cell lines

Novel selective Nav1.1 activator, increasing the firing activity of parvalbumin-expressing, fast-spiking GABAergic interneurons and increasing the spontaneous inhibitory post-synaptic currents (sIPSCs) recorded from pyramidal neurons

Novel HIF-1α prolyl hydroxylase inhibitor

Selective, orally active 5-HT6 antagonist

Functional Agonist of the Apelin (APJ) Receptor

A stable, cell-permeable, non-competitive adenylyl cyclase inhibitor

Potent MTH1 inhibitor; RAS​/RAC-​mediated membrane ruffling inhibitor

Inducer of apoptosis

Novel potent inhibitor of protein kinase CK2

Potent and selective phospholipase D1inhibitor

An active opioid receptor antagonist

A second-generation irreversible pan-erbB receptor tyrosine kinase inhibitor

Orally effective Fe chelator. being more active than desferrioxamine

A fluorescent, amyloid-specific dye. It binds at a different site than Pittsburgh Compound B and is a highly fluorescent marker for beta-sheet structures

A highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells, displaying a green fluorescence off-on change induced by the TrxR-mediated disulfide cleavage and subsequent intramolecular cyclization to liberate the masked n

Fluorescent analogue of the dopaminergic neurotoxin MPP+