Novel Fluorescent Probe of Blood-Brain Barrier Disruption in Animal Models

The first inorganic phosphate (Pi) targeted colorimetric and fluorescent probe to detect endogenous Pi in hemichannelclosed cells

Novel chemical probe for heterochromatin formation and function, disrupting of heterochromatin-mediated transcriptional gene silencing

Direct iron chelator from β(2) subunit of ribonucleotide reductase

Anti-fibrotic agent, acting as an adiponectin receptor (AdipoR) agonist

Potent and Highly Selective Inhibitors of GSK3b

Dopamine and the D1 receptor agonist, stimulating phosphoinositide hydrolysis

Analog of GSK199 inhibiting PAD4

Novel selective androgen receptor modulator, preventing body weight loss and sarcopenia in cancer cachexia models

The first highly potent and selective KDM5 inhibitor

Novel tubulin and HSP90 dual inhibitor, causing the destabilization of microtubules and degradation of HSP90 client proteins CRAF-1 and ERBB2, resulting in cell cycle arrest at the G2/M phase and apoptosis

Novel small molecule activator of PP2A (SMAP), negatively regulating c-myc in small cell lung cancer

Novel selective inhibitor of primordial germ cell (PGC) development, targeting poly(A)-tail-independent noncanonical translation (PAINT)

Isomer of KLH45 (AOB5741)

Novel Sirtuin-3 Inhibitor, Inhibiting Cell Survival and Proliferation, and Promoting Apoptosis of Head and Neck Cancer Cells

Novel Nur77 modulator, inducing apoptosis of cancer cells by activating the Nur77-Bcl-2 apoptotic pathway

First-in-class nudix hydrolase family inhibitor, potently and selectively engaging and inhibiting the MTH1 protein in cells

Clickable adenosine derivative, to capture newly polyadenylated transcripts, and next-generation sequencing reveals mRNA sequence motifs that are linked to polyadenylation

Standard for Ca2+ channel activativation