MDK08445 is an important intermediate or precursor for the synthesis of Cefiderocol. MDK08445 has CAS#1225208-44-5. We assigned a code name as MDK08445 (last 5 digital of its CAS# was used). Cefiderocol, also known as S-649266, is a potent siderophore cephalosporin antibiotic with a catechol moiety on the 3-position side chain. S-649266 shows potent in vitro activity against the non-fermenting Gram-negative bacteria Acinetobacter baumannii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, including MDR strains such as carbapenem-resistant A. baumannii and metallo-β-lactamase-producing P. aeruginosa.

An antimicrobial peptide with angiogenic properties, AG-30/5C, activates human mast cells through the MAPK and NF-κB pathways.

TAMRA-PEG4-Alkyne is a TAMRA red-fluorescent dye derivative with excitation/emission maximum 553/575 nm, containing an alkyne group which enables Click Chemistry.

alpha-Amyl cinnamaldehyde is a common additive in perfume and cosmetic industry as aroma substance. It is found naturally in the essential oil of chamomile.

N,N-Diphenylamine is an aromatic amine containing two phenyl substituents. It has been used as a fungicide for the treatment of superficial scald in apples and pears, but is no longer approved for this purpose within the European Union. It has a role as a carotogenesis inhibitor, an antioxidant, an EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor and an antifungal agrochemical. It is an aromatic amine, a secondary amino compound and a bridged diphenyl fungicide.

Simazine is a chlorotriazine herbicide and pesticide. It may cause testicular degeneration, neuroendocrine disruption, mammary cancer, and fetal developmental delays.

Cyanine5 alkyne for Click Chemistry, an analog of Cy5 alkyne. With this product, deeply colored, and photostable Cyanine5 fluorophore can be attached to various molecules via Click Chemistry reaction with azides. This alkyne is non-water soluble, but it can be dissolved in DMF or DMSO prior to reaction, and added to aqueous reaction mixture. With our labeling protocol, the labeling reaction is very efficient, and high-yielding. Various substrates bearing azides can be used for the labeling, including azido-labeled biomolecules, polymers, and solid surfaces.

C.I. Pigment Red 172 is a Former food dye prohibited from use in foods.

FD&C Yellow No. 5 Aluminum Lake is a synthetic lemon yellow azo dye primarily used as a food coloring.

Gymnemic acids have been reported to effect a natural treatment for diabetes. Gymnemic acids inhibit rabbit glyceraldehyde-3-phosphate dehydrogenase and induce a smearing of its electrophoretic band and dephosphorylation. Gymnemic Acid Stimulates In Vitro Splenic Lymphocyte Proliferation.

Propargyl-PEG1-amine is a PEG derivative containing a propargyl group and an amino group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Methyl 4-anisate is a biochemical.

t-Boc-N-Amido-PEG4-propargyl is a PEG derivative containing a propargyl group and Boc-protected amino group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

3-HIB is a paracrine regulator of trans-endothelial fatty acid transport.

Isophthalic acid is an intermediate for high performance unsaturated polyesters, resins for coatings, high solids paints, gel coats and modifier of polyethylene terephthalate for bottles.

7,8-Dihydroneopterin is a pteridine with antioxidant activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals and inhibits copper ion-induced oxidation of LDL. It also decreases thiobarbituric acid reactive substances (TBARS) produced by THP-1 cells cultured with LDL, and it inhibits necrosis induced by oxidized LDL (oxLDL).

m-Nitroacetophenone is used for increasing ESI multiple charging of proteins and protein complexes.

Desertomycin A is fungal metabolite and the major component of the desertomycin antibiotic complex.

Biotin-PEG4-alcohol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.

GO-Y078 is an antiangiogenic curcumin analog which inhibits actin stress fiber formation, thereby resulting in mobility inhibition.

N(1),N(11)-Diethylnorspermine tetrahydrochloride is a highly potent known inducer of the polyamine catabolic enzyme, spermidine/spermine N1-acetyltransferase (SSAT). A designed polyamines (PAs) analog which induces cell cycle arrest, inhibits proliferation and induces apoptosis in melanoma, breast, prostate, lung and colon cancer cells.

3'-Hydroxyacetophenone is a biochemical.

Deacylgymnemic acid is a macrocyclic compound for proteomics research.

Durapatite is also known as hydroxyapatite. It is he mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.

Carbarsone is sometimes used in treatment of intestinal amoebiasis.

Sulfanilic acid, as the compound readily forms diazo compounds, it is used to make dyes and sulpha drugs. This property is also used for the quantitative analysis of nitrate and nitrite ions by diazonium coupling reaction with N-(1-Naphthyl)ethylenediamine, resulting in an azo dye.

4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity. It is cytotoxic to A2780 ovarian cancer cells but not to carboplatin-resistant A2780 cells. It is selective for A2780 cells over non-cancerous ARPE19 cells. 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.

Metanilic acid is an anti-cancer drug used to treat several malignancies including pediatric acute lymphoblastic leukemia and choriocarcinoma.

Benzyladenine is a plant growth regulator. When complexed with gold, the derivatives exhibit cytotoxicity and anti-inflammatory activity.

Azido-PEG8-acid is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.