Quorum sensing modulator as a LasR antagonist

Novel

Novel kidney urea transporter UT-A1 inhibitor

Novel USP30 inhibitor, increasing Ub-TOM20 with an EC50 of 2.45 mM and inducing the maximal Ub-TOM20

Novel H2 receptor agonist, functionally stimulating human cardiac H2 receptors in vitro and in vivo

Novel fluorescent histamine H3 receptor ligand

Novel NPY Y1 Receptor Antagonist

Novel H2 receptor agonist, functionally stimulating human cardiac H2 receptors in vitro and in vivo

Novel H2 receptor agonist, functionally stimulating human cardiac H2 receptors in vitro and in vivo

Novel subtype selective histamine H2 receptor G protein-biased agonist

Py-5-Labeled Fluorescent Multipurpose Probe for Investigations on the Histamine H3 and H4 Receptors, acting as a partial agonist at the hH3R [pEC50 (reporter gene) 8.77] and as an inverse agonist/antagonist at the h/mH4Rs [pIC50 (reporter gene) 8.76/7.08;

Novel potent partial agonist of histamine H4 receptors (H4R)

Novel potent partial agonist of histamine H4 receptors (H4R)

Potent, selective, and irreversible inhibitor of fatty acid amide hydrolase (FAAH)

Novel FAAH inhibitor

Novel Red-Emitting Fluorescent Dualsteric Probe for the Muscarinic Acetylcholine M2 Receptor

Natural flavonoid from the leaves of Glycyrrhiza uralensis

Novel Potent Neuropeptide Y Y4 Receptor (Y4R) Partial Agonist (pK i : 8.47)

Novel Neuropeptide Y Y4 Receptor (Y4R) Antagonist (pK i values <7.57)

Novel E-Selectin antagonist, disrupting cell survival pathway activation, enhancing chemotherapy response and protecting from toxicity such as mucositis with improved survival in vivo

Novel potent antagonist of the Urotensin-II (UT) receptor

Novel superagonist of the urotensin-II (UT) receptor

Novel Potent antagonist of the Urotensin-II (UT) Receptor

Novel superagonist of the urotensin-II (UT) receptor

Potent kynurenine 3-monooxygenase (kynurenine 3-hydroxylase; KMO) inhibitor

The first bifunctional (chemoreactive and clickable) probe for Adenosine A1 and A3 Receptors

Novel β-arrestin-biased D2 receptor (D2R) agonist

Novel potent and selective PAM of CBX8, blocking H3K27me3 binding and enhancing CBX8 affinity for nucleic acids, evicting PRC1 from H3K27me3 targets triggering DLBCL cell differentiation

Novel inhibitor for histone methyllysine reader proteins (KmeRP), targeting CBX5 chromodomain

Novel peptidomimetic antagonist of the PHF1 Tudor domain, binding both PHF1 Tudor domain and the related protein PHF19