Novel antibiofilm agent, disturbing symbiotic balance between C. albicans and S. mutans in dual species biofilm

Prodrug of Thiamphenicol, inhibiting the 50S subunit of the bacterial ribosome and protein translation

Novel glutaminase activity inhibitor, showing a partial uncompetitive inhibition in vitro and a significant reduction of ammonia and glutamate production in vivo

Natural antibiotic, being active against P. aeruginosa both in vitro and in vivo.

Natural potent human carboxylesterase 2 (hCES2) inhibitor (IC50: 5.05 μM)

Novel highly potent and specific inhibitor of TLR8, targeting an unconventional pocket on the TLR8 protein-protein Interface

Potent and selective inhibitor of PI 3-K

Cell-permeable, potent, and selective inhibitor of PI 3-K isoforms p110ß/p110d

Novel Potent Agonist of TGR5 Receptor

Novel potent TGR5 agonist, displayind a significant glucose-lowering effect and stimulated GLP-1 and insulin secretion in TGR5H88Y mice but not in wild-type animals

Novel potent and structure-specific inhibitor of pre-miR-200c, reversing a type 2 diabetes phenotype

Potent and Selective Antagonist for Human EP2 Receptors

Potent and selective nociceptin opioid receptor (NOP) agonist

Potent and selective nociceptin opioid receptor (NOP) agonist

Potent and selective nociceptin opioid receptor (NOP) agonist

EP2 allosteric potentiator

Highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (TG2) inhibitor

Novel inhibitor of mitochondrial calcium uptake (#333333; font-family: "Open Sans", HelveticaNeue, "Helvetica Neue", Helvetica, Arial, sans-serif; font-size: 15px; font-style: normal; font-variant-ligatures: normal; font-variant-caps: normal; font-weight:

Novel, Potent, Selective, Water Soluble, Brain-Permeable EP2 Receptor Antagonist

Novel inhibitor of T315I mutant enzyme, exhibiting reasonable in vivo efficacy in a xenograft mouse model harboring T315I

Novel dual VEGFR/Src kinase inhibitor

Novel potent SARS coronavirus (CoV) 3CL protease inhibitor (Ki = 53 nM)

Novel and Potent Stem Cell Mobilizer; Inhibitor of SDF-1α/CXCR4 binding

Cyclized tamoxifen analog, selective ER modulator (SERM)

CNS-penetrant selective class IIa histone deacetylase (HDAC) inhibitor, exploiting the >100-fold selectivity over class I/IIb HDACs

Novel cell-active, selective class IIa HDAC inhibitor

Novel GSK-3β inhibitor, showing anti-neuroinflammatory effects in lipopolysaccharide (LPS) activation of spontaneously immortalized SIM-A9 microglial cells and of mouse cortical microglia, inhibiting LPS-induced production of nitric oxide and the proinfla

Novel multipotent anti-Alzheimer agent, selectively inhibiting human butyrylcholinesterase (BChE), having strong antioxidant activity and good β-amyloid (Aβ) anti-aggregation properties

Novel endothelin (ET) receptor antagonist

Potent and selective human leukocyte 5-lipoxygenase (5-LOX) inhibitor