Novel GSK-3β inhibitor, showing anti-neuroinflammatory effects in lipopolysaccharide (LPS) activation of spontaneously immortalized SIM-A9 microglial cells and of mouse cortical microglia, inhibiting LPS-induced production of nitric oxide and the proinfla

Novel multipotent anti-Alzheimer agent, selectively inhibiting human butyrylcholinesterase (BChE), having strong antioxidant activity and good β-amyloid (Aβ) anti-aggregation properties

Novel endothelin (ET) receptor antagonist

Potent and selective human leukocyte 5-lipoxygenase (5-LOX) inhibitor

Antitubercular agent

Inducer of S phase arrest and apoptosis in hepatocellular carcinoma QGY-7701

Potent inhibitor of protein synthesis, inhibiting translation by binding within the ribosomal exit tunnel

Activator of the hepatic interferon pathway in rats

Reversible inhibitor of vesicular monoamine transporter 2, showing anti-chorea effect and decreasing uptake of monamines into synaptic vesicles, as well as depletion of monoamine storage

Mutually Orthogonal Bioorthogonal Amino Acid, Enabling Efficient Protein Dual-Labeling in Cells

Selective Thromboxane_receptor>thromboxane receptor antagonist

Peptide vaccine, residues (611-626) of the human telomerase reverse transcriptase catalytic subunit (hTERT), for the treatment of solid cancers

COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory agent

Photosensitizing agent used in the treatment of squamous cell carcinoma of the head and neck, also showing activity agaimst COVID-19 Mpro

Mucolitic agent, inhibiting activation of nuclear factor kappa-κB (NF-κB) by blocking phosphoinositide 3-kinase/protein kinase B (PI3K/Akt)/IκB kinase (IKK) activities, showing the anti-inflammatory properties on inflammation-associated skin diseases

Potent and selective M1 antimuscarinic

Natural antibacterial agent, being active against gram-positive bacteria.

Novel monocyte/macrophage targeted histone deacetylase inhibitor

Novel antimalarial agent

Novel inhibitor of the p53-Hdm2 protein-protein interaction, dose-dependently stabilized P53 and increased P21 and MDM2 expression in JAR choriocarcinoma cells, inducing the p53 regulated gene (PIG-3) and caspase activity

Novel potent inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1)

Novel Specific Copper Chelator, Reducing Memory Impairments in Alzheimer's Disease Mouse Models

Hepatotoxicity inducer, significantly up-regulating the expression of genes involved in endoplasmic reticulum stress and Toll-like receptor (TLR) pathway

Novel long-acting β 2 -adrenoceptor agonist

Novel potent BET protein degrader, inhibiting cell proliferation due to suppressed C-MYC transcription

Novel selective opioid receptor antagonist at all three receptor types

Novel IKZF1/3 degrader, inhibiting the proliferation of multiple myeloma cells in vitro as well as in vivo

Novel degrader of the anaplastic lymphoma kinase (ALK) fusion protein, effectively inducing ALK degradation and inhibiting the growth of ALK fusion positive cell lines, SU-DHL-1 and H3122, significantly reducing the tumor growth in H3122 xenograft model

Sorafenib analogue, retaining cytotoxicity similar to sorafenib in various human cancer cell lines and strongly inhibiting growth in the NCI-60 cell line panel

Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor