Novel SAM Competitive PRMT5 Inhibitor, Demonstrating Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance

Novel prdrug of PF-06843195, a potent PI3Kα-selective inhibitor

Novel potent and selective inhibitor of MAP4K4

Novel tyrosine residues probe, rationally targeting active site

Novel potent and selective inhibitor of MAP4K4

Novel non-brain-penetrant long-acting peptide oxytocin (OT) receptor agonist with increased selectivity for the OT receptor and significantly increased pharmacokinetic stability

Novel potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor

Novel potent TRPV4 antagonist (hTRPV4 IC50 4nM; rTRPV4 IC50 27nM)

Novel selective hTRPV4 Antagonist (hTRPV4 IC50 49nM; rTRPV4 IC50 1,150nM)

Irriversible inhibitor of kynurenine amino transferase II (KAT II)

Novel potent and selective PDE8B/8A inhibitor

Selective dopamine D3/D2 receptor antagonist

Dose dependent inhibitor of multiple fibrotic genes

Novel γ-secretase inhibitor

First Inhibitor of PEX14-PEX5 Protein-Protein Interaction (PPI) with Trypanocidal Activity

Novel allosteric inhibitor of E. coli Hsp70 (DnaK) and human Hsp70 proteins

Non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor

Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation

Agonist of dopamine receptor subtypes D1 and D2

Broad-spectrum virus- and host-targeting peptide, inhibiting coronaviruses and other respiratory viruses

ApoA-I/HDL mimetic peptide, efficiently crossing the blood-brain barrier and modulating amyloid beta distribution between brain and plasma

Innate defense regulator, target stringent response-controlled virulence in a Pseudomonas aeruginosa murine cutaneous infection model

Inhibitor of calcium-dependent complex formation with p53 [(Ca)S100B-p53] in malignant melanoma (MM), restoring p53 tumor suppressor activity in vivo

Novel potent and broad-spectrum anti-influenza A virus (anti-IAV) activities with low risk of inducing drug resistance

Antibiotic, a natural penicillin, synthesized in vitro by incubating (S-octanoyl)glutathione, 6-APA and AT

Mycotoxin with antibiotic and carcinogenic activity

Antineoplastic agent, alkylating and crosslinking DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis

Novel caged glutamate

Cyclooxygenase Inhibitor and Prostagladin Synthase Inhibitor

Activator of SHIP-1