Potent and selective

Novel potent competitive γ-aminobutyric acid type A receptor (GABA A R) antagonist (K i = 180 nM), targeting extrasynaptic α4βδ subtype, showing efficiently rescue inhibition of T cell proliferation

Novel G6PD inhibitor, revealing immune dependence on pentose phosphate pathway. depleting NADPH most strongly in lymphocytes, markedly decreasing inflammatory cytokine production in T calls, suppressing respiratory burst in neutrophils

Novel antibacterial and anti-biofilm agent against antibiotic resistant clinical isolates

Inhibitor of NLRP3 inflammasome

Novel fluorescent specific ligand of human telomeric G-quadruplex DNA, binding to both G-tetrad and the lateral loop near the 5-end, reducing the telomere length and downregulating hTERC and hTERT mRNA expression in HeLa cells

Novel potent and highly specific MEK inhibitor (MEKi)

Novel antiviral agent against Rift Valley fever virus (RVFV) by blocking virus budding from the trans Golgi.

Novel, Potent, and Nonsteroidal Farnesoid X Receptor (FXR) Selective Antagonist

Novel potent and selective inhibitor of FXIa, producing a robust and dose-dependent inhibition of both arterial thrombosis and MES

Novel highly potent Factor XIa inhibitor with selectivity against most of the relevant serine proteases

Novel slow-releasing hydrogen sulfide (H2S) donor, inhibiting NF-κB activity and inducing cell apoptosis

Natural neuroprotective agent on glutamate-mediated HT22 cell death, controlling the amount of ubiquinone, up-regulating p21 expression in a p53-dependent manner, decreasing Akt phosphorylation and resulting in increased Fas ligand production and caspase-

Insecticide, acting as an EC 3.1.1.7 (acetylcholinesterase) inhibitor

Novel potent Hepatitis C virus (HCV) NS3/4A protease inhibitor

Anti-bacterial metabolite of Nitrofuran

Highly potent dopamine D2 modulator

Chemosensitizing agent, selectively reversing BCRP-mediated multidrug resistance to mitoxantrone, doxorubicin, and topotecan

Natural antimicrobial agent, showing neuroprotective, expectorant, and antioxidant activities

Direct inhibitor of the p53 transactivation domain from binding to replication protein A

FTY720 analog as novel stimulator of the activity of the protein phosphatase 2A (PP2A), targeting mitochondria

FTY720 analog as novel potent stimulator of the activity of the protein phosphatase 2A (PP2A)

Novel specific high-affinity fluorescent probe for FtsZ antibacterial inhibitor

Novel fat mass- and obesity-associated protein (FTO) inhibitor, preventing neurosphere formation in patient-derived glioblastoma stem cells (GSCs) without inhibiting the growth of healthy neural stem cell-derived neurospheres

Farnesyltransferase inhibitor, inhibiting both H- and K-Ras oncogenic signaling

Novel inhibitor of protein farnesyltransferase (FT), inhibiting the growth of P. falciparum in red blood cells and suppressing parasitemia

Novel Anabolic Selective Androgen Receptor Modulator (SARM)

Novel highly potent and selective inhibitor (type 1.5 binding mode) of MAPK14 [IC50 = 0.2 nM (ELISA, cell free); KD = 1.5 nM (DiscoverX)]

Novel N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulator (PAM) with potential antidepressant effects

Potent ligand for a protein site governed largely by van der Waals interactions, producing excitatory activity in tadpoles and mice; also antagonizing propofol-induced hypnosis