Novel acetylcholinesterase inhibitor

Novel dual inhibitor of cholinergic dysfunction and amyloid deposition for AD treatment, penetrating the blood-brain barrier (BBB) and enhancing the cerebral acetylcholine level

Novel potent and orally active ChemR23 inhibitor (IC 80 = 12 nM), showing a long-acting effect in cynomolgus monkeys

Inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase

Novel inhibitor against Lactate Dehydrogenase (LDH) of Cryptosporidium parvum

Novel intracellular chelator, disrupting iron homeostasis in bacteria

Novel potent and selective kynurenine mono-oxygenase (KMO) inhibitor

The desmethyl precursor of CHDI-180R which is a first-in-class high-affinity PET imaging ligand specific for mHTT aggregates

Novel inhibitor of mitochondrial respiration, targeting drug-resistant cancer cells with stem-like features by inhibiting mitochondrial respiration complex I (NADH:ubiquinone oxidoreductase, complex I [CI])

Novel Hsp90 inhibitor

Potent Androgen_receptor>androgen receptor (AR) pure antagonist which did not produce the agonist metabolite

Novel Hsp90 inhibitor

Novel microtubule polymerization inhibitor with little susceptible to transporter-mediated chemoresistance

Novel Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitor

The first small-molecule based MCM2-targeted NIR-II probe

Benzodiazepine receptor partial agonist

Benzodiazepine antagonist

Water soluble CycLuc3, mutant firefly luciferase variant with enhanced light emission

Matrix metalloproteinase (MMP) inhibitor

Mutant firefly luciferase variant with enhanced light emission

Broad spectrum matrix metalloproteinase (MMP) inhibitor

Liver specific thyromimetic agonist of thyroid hormone receptor-

Peptoid Tat/transactivation response element inhibitor, inhibiting human immunodeficiency virus replication by blocking CXC-chemokine receptor 4-mediated virus entry

Novel HIV-1 protease inhibitor, also potently inhibiting major aspartyl peptidase 1 (May1), a secreted Cryptococcus neoformans protease

Activator of RORalpha, inducing growth arrest in androgen-independent DU 145 prostate cancer cells

Non-peptide tachykinin NK1 receptor antagonist

Novel inhibitor of Wnt/β-catenin signaling; Anticancer agent promoting PKCα-mediated β-catenin phosphorylation/degradation

Novel Bruton's tyrosine kinase (BTK) inhibitor

Novel functional Gboxin analogue that is suitable for live-cell ultraviolet crosslink conjugation and click chemistry

Novel PRL-3 inhibitor, blocking the migration and invasion of metastatic cancer cells