OUL35 |CAS 6336-34-1|DC Chemicals

Cas No.:	6336-34-1
Chemical Name:	OUL35
Synonyms:	4-(4-carbamoylphenoxy)benzamide;4,4'-oxydibenzamide;4,4'-Oxy-di-benzoesaeure-diamid;4,4'-oxy-di-benzoic acid diamide;4.4'-Oxy-bis-benzamid;4,4′-Oxybis-benzamide;4-(4-Carbamoylphenoxyl)benzamide;NSC 39047;NSC39047;OUL35
SMILES:	NC(C1=CC=C(OC2=CC=C(C(=O)N)C=C2)C=C1)=O
Formula:	C₁₄H₁₂N₂O₃
M.Wt:	256.25700
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

OUL35 (NSC39047) is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of 330 nM, displays remarkable selectivity towards ARTD10 over other enzymes in the human protein family; rescues cells from ARTD10 induced cell death, sensitizes cancer cells to the hydroxyurea-induced genotoxic stress; OUL35 is a cell biology tool compound for selective inhibition of ARTD10-mediated MARylation and investigation of ARTD10 in DNA-damage repair.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

Cat. No.	Product name	Field of application
DC73217	Thioparib	Thioparib is a next-generation potent, orally bioavailable pan-PARP inhibitor with IC50 of 0.13/0.006 nM (PARP1/2), overcomes multiple PARPi resistance both in vitro and in vivo.
DC72591	OUL232	OUL232 is a potent inhibitor of mono-ARTs PARP7, PARP10, PARP11, PARP12, PARP14, and PARP15. OUL232 is the most potent PARP10 inhibitor described to date (IC50=7.8 nM), as well as the first PARP12 inhibitor ever reported.
DC70175	AEP07	AEP07 (AEP 07) is a selective small molecule inhibitor of PARP4 (vPARP) inhibitor with IC50 of 0.8 uM, >12-fold selective over other PARP family members.
DC45193	DR2313	DR2313 is a potent, selective, competitive and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively. DR2313 exhibits neuroprotective effects on ischemic injuries in vitro and in vivo.
DC39102	RBN012759	RBN012759 is a potent and selective inhibitor of PARP14 with IC50 of <3 nM and 5 nM for human catalytic domain and mouse catalytic domain, respectively. RBN012759 contributes to anti-tumor immune response.
DC11022	OUL35	OUL35 (NSC39047) is a potent and selective inhibitor of mono-ADP-ribosyltransferase PARP10/ARTD10 with IC50 of 330 nM, displays remarkable selectivity towards ARTD10 over other enzymes in the human protein family.
DC11504	GeA-69	GeA-69(GeA69) is a potent, selective, allosteric, cell-active PARP14 macrodomain 2 (MD2) inhibitor with Kd of 0.86 uM in ITC assays.
DC10056	AZ9482	AZ9482, a potent and selective PARP inhibitor featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine.
DC7046	A-966492	A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively.