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Ruzasvir

  Cat. No.:  DC11731  
Chemical Structure
1613081-64-3
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More than 5000 active chemicals with high quality for research!
Field of application
A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively..
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1613081-64-3
Chemical Name: Dimethyl N,N'-([(6S)-6-(2-cyclopropyl-1,3-thiazol-5-yl)-1-fluoro-6H-indolo[1,2-c][1,3]benzoxazine-3,10-diyl]bis{(1H-imidazole-4,2-diyl)[(2S)-pyrrolidine-2,1- diyl][(2S)-3-methyl-1-oxobutane-1,2-diyl]})dicarbamate
Synonyms: MK-8408;MK 8408;MK8408
SMILES: O1C2=CC(C3=CNC([C@H]4CCCN4[C@H](C(C)C)C(NC(OC)=O)=O)=N3)=CC(F)=C2C2=CC3=C(N2[C@H]1C1SC(C2CC2)=NC=1)C=CC(C1=CNC([C@H]2CCCN2[C@H](C(C)C)C(NC(OC)=O)=O)=N1)=C3
Formula: C49H55FN10O7S
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC8612 Simeprevir(TMC-435) Simeprevir (TMC 435350) is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
DC8178 Beclabuvir(BMS-791325) non-nucleoside inhibitor of the NS5B
DC11494 INX-08189 INX-08189 is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
DC11081 Coblopasvir Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection..
DC11731 Ruzasvir A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively..
DC11825 MK-8876 A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively.
DC11823 BMS-929075 A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively.
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