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Simeprevir(TMC-435)

  Cat. No.:  DC8612  
Chemical Structure
923604-59-5
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More than 5000 active chemicals with high quality for research!
Field of application
Simeprevir (TMC 435350) is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 923604-59-5
Synonyms: TMC435; TMC435350; TMC-435350
SMILES: COC1=CC=C2C(=CC(C3SC=C(C(C)C)N=3)=NC2=C1C)O[C@H]1C[C@H]2C(N(CCCCC=C[C@@H]3C[C@]3(NC(=O)[C@@H]2C1)C(NS(C1CC1)(=O)=O)=O)C)=O |t:34,&1:22,24,33,35,39|
Formula: C38H47N5O7S2
M.Wt: 749.94
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC8612 Simeprevir(TMC-435) Simeprevir (TMC 435350) is a potent inhibitor of HCV NS3/4A protease (Ki = 0.36 nM) and viral replication (replicon EC50 = 7.8 nM).
DC8178 Beclabuvir(BMS-791325) non-nucleoside inhibitor of the NS5B
DC11494 INX-08189 INX-08189 is a phosphoramidate prodrug of O-6-methyl-2-C-methyl guanosine, potent inhibitor of HCV NS5B polymerase with IC50 of 10 nM in replicon assay.
DC11081 Coblopasvir Coblopasvir (KW136, KW-136) is a novel HCV NS5A inhibitor under development for treatment of HCV infection..
DC11731 Ruzasvir A potent, pan-genotype HCV NS5A inhibitor with replicon EC90 of 0.003, 0.016, 0.067, 0.036, 0.007, and 0.007 nM for GT1a, GT1a L31V, GT1a Y93H, GT2b, GT3a, and Gt4a, respectively..
DC11825 MK-8876 A novel, broadly acting non-nucleoside inhibitor of HCV NS5B polymerase with IC50 of 3 nM and 2 nM for GT1b and GT2a, respectively.
DC11823 BMS-929075 A highly potent, selective, orally bioavailable HCV NS5B polymerase inhibitor with IC50 of 9, 4, and 18 nM for GT1a, GT1b, and GT1b-C316N mutant in HCV replicon assay, respectively.
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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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