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AUT-1

  Cat. No.:  DC11999   Featured
Chemical Structure
1311136-84-1
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More than 5000 active chemicals with high quality for research!
Field of application
AUT-1 is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1311136-84-1
Chemical Name: (5R)-5-ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione
Synonyms: AUT-1;AUT 1
SMILES: C1(N(C2C=NC(OC3C=C(OC)C(C)=CC=3)=CC=2)C(=O)[C@H](CC)N1)=O
Formula: C18H19N3O4
M.Wt: 341.361164331436
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: AUT1 is a Kv3 potassium channel modulator, with pEC50s of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively, exhibits 10-fold lower potency at human recombinant Kv3.3 channel (pEC50, 4.5)[1].
Target: pEC50: 5.33 (Human recombinant Kv3.1b), 5.31 (Human recombinant Kv3.2a), 4.5 (Human recombinant Kv3.3)[1]
References: [1]. Rosato-Siri MD, et al. A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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