DPO-1|CAS 43077-30-1|DC Chemicals

Cas No.:	43077-30-1
Chemical Name:	DPO-1
Synonyms:	DPO-1;[[(1S,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzene;HMS3261N07;HMS3269O11;neomenthyldiphenylphosphine oxide;Neomenthyldiphenylphosphin-oxid;(+)-Neomenthyl diphenylphosphine oxide;(1S,2S,5R)-5-Methyl-2-(1-methylethyl)cyclohexyl]diphenyl-phosphine oxide
SMILES:	C[C@@H]1CC[C@@H](C(C)C)[C@@H](P(C2C=CC=CC=2)(=O)C2C=CC=CC=2)C1
Formula:	C₂₂H₂₉OP
M.Wt:	340.43886
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Lagrutta A, et al. Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current. J Pharmacol Exp Ther. 2006 Jun;317(3):1054-63. [2]. Stump GL, et al. In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther. 2005 Dec;315(3):1362-7.

Description:

DPO-1 is a potent inhibitor of the voltage-gated potassium channel subtype Kv1.5 and a blocker of ultrarapid delayed rectifier potassium current. DPO-1 prevents atrial arrhythmia.

References:

[1]. Lagrutta A, et al. Novel, potent inhibitors of human Kv1.5 K+ channels and ultrarapidly activating delayed rectifier potassium current. J Pharmacol Exp Ther. 2006 Jun;317(3):1054-63. [2]. Stump GL, et al. In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide. J Pharmacol Exp Ther. 2005 Dec;315(3):1362-7.

MSDS

COA

LOT NO.	DOWNLOAD
2018-0101

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