XE-991 is a potent, selective and orally active blocker of voltage-gated potassium channels Kv7 (KCNQ) that blocks KCNQ1, KCNQ2 and KCNQ2+KCNQ3 with Kd of 0.78, 0.7 and 0.6 uM, respectively.

Quisinostat, also known as JNJ-26481585, is an orally bioavailable, second-generation, hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. HDAC inhibitor JNJ-26481585 inhibits HDAC leading to an accumulation of highly acetylated histones, which may result in an induction of chromatin remodeling; inhibition of the transcription of tumor suppressor genes; inhibition of tumor cell division; and the induction of tumor cell apoptosis. HDAC, an enzyme upregulated in many tumor types, deacetylates chromatin histone proteins. Compared to some first generation HDAC inhibitors, JNJ-26481585 may induce superior HSP70 upregulation and bcl-2 downregulation.

Finerenone (BAY 94-8862) is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC50=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease.

Dodecyltrimethylammonium bromide (DTAB) is a surfactant. Dodecyltrimethylammonium bromide interacts with DNA and changes the mechanical properties of DNA on binding and the specific binding parameters of the interaction.

Tetradecyltrimethylammonium bromide, an organic building block, is a cationic surfactant with asymmetrical structure.

CTAB(Cetyltrimethylammonium bromide) is a quaternary ammonium surfactant commonly used in various fields such as chemistry, biology, and material science. Structure: CTAB consists of a long hydrocarbon chain (cetyl group) attached to a positively charged nitrogen atom. The cetyl group provides hydrophobic properties to the molecule, while the positively charged nitrogen offers a hydrophilic head.

LY3473329 (Muvalaplin) is a potent, multivalent disruptor of lipoprotein(a) (Lp(a)). LY3473329-HCl binds to apolipoprotein KIV8 selectively with a potency of 22 nM and inhibits the formation of Lp(a) particles in vitro with IC50 of 0.09 nM.

DB2313 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 29 nM.

WAY-340935 (VEGFR2-IN-2) can inhibit the function of VEGFR2 and the anti-proliferative activity against the H460 cell line is produced partly by interaction of VEGFR protein.

Fmoc-Val-Cit-PAB-MMAE consists the ADCs linker (Fmoc-Val-Cit-PAB) and potent tubulin inhibitor (MMAE). Fmoc-Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

Because the solubility parameters of polyacrylate and uncured epoxy resin have little difference, the two have good mutual solubility. And because the main chain of polyacrylate does not contain double bonds, it has a good thermal oxidation resistance. Acrylate PEG derivatives can be used to modify proteins, peptides and other active group materials or small molecules. Acrylate PEG derivatives can form hydrogels. Polyethylene glycol can increase solubility and stability. Reducing the immunogenicity of peptides and proteins, it can also inhibit the non-specific binding of charged molecules on the modified surface.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

DOPE-PEG-Biotin is a bilateral active PEG derivative, also known as PEG (polyethylene glycol) modifier, modified PEG, etc. PEG is a functional group that is currently mainly used for protein drug modification to increase the half-life in vivo and reduce immunogenicity, while also increasing the water solubility of the drug. PEG derivatives have been widely used in pharmaceutical research and development in recent years, and play an important role in the sustained release of drugs. Biotin has a high binding force on avidin or streptavidin, and the biotin/avidin system is widely used in the detection and separation of biomolecules.

Folic Acid (Folic Acid), also known as pteroyl glutamate, is a water-soluble vitamin, is a light orange yellow crystal or sheet, the molecular formula is C19H19N7O6, the molecular weight is 441.4 because of the rich content in green leaves. There are several forms in nature, and its parent compound is a combination of pteridine, p-aminobenzoic acid and glutamic acid. PEG derivatives are also known as PEG (polyethylene glycol) modifiers, modifying PEG, etc. PEG is a functional group that is currently mainly used for protein drug modification to increase the half-life in vivo and reduce immunogenicity, while also increasing the water solubility of the drug. PEG derivatives have been widely used in pharmaceutical research and development in recent years, and play an important role in the sustained release of drugs. DOPE Conjugate pegylates are phospholipids and pegylates combined with hydrophilic and hydrophobic properties. Polyethylene glycol phospholipid liposome forming material can be used for drug delivery, gene transfection and vaccine delivery.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. Heparin, named after its discovery in the liver, is a mucopolysaccharide sulfate composed of glucosamine, L-idosaccharide, n-acetylglucosamine and D-glucuronic acid, with an average molecular weight of 15KDa and a strong acid. It is also found in tissues such as lungs and intestinal mucosa, and is a natural anticoagulant in animals. Naturally occurring in mast cells, it is now mainly extracted from the mucous membrane of the bovine lung or the small intestine of pigs. As an anticoagulant, it is a polymer formed by alternating connection of two polysaccharides, which has kang coagulation effect in vivo and in vitro, mainly used in xueshaun embolic diseases, cardiac xuguan surgery,xinzang catheterization, extracorporeal circulation, hemodialysis and so on. With the development of pharmacology and clinical medicine, the application of heparin continues to expand.

BAY-2965501 is a first-in-class a diacylglycerol kinase zeta (DGKζ, lipid kinase) inhibitor with IC50 of 27 nM/35 nM (human/mouse) and shows >20-fold selectivity for DGKζ over other DGK isotypes. BAY-2965501 blocks DGKζ in T-cells to activate them

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers. A covalent bond in the carbonyl group is connected to the hydrogen atom and formed by a univalent atomic group, called aldehyde group, aldehyde group structure simple formula is -CHO, aldehyde group is a hydrophilic group, so the organic matter with aldehyde group (such as acetaldehyde, etc.) has a certain water solubility. Aldehydes, sugars, aldehydes, glucose, maltose and other molecules contain aldehyde groups. The aldehydes are active and prone to condensation and nucleophilic addition reactions. The aldehyde group can be reduced to hydroxymethyl (-CH2OH) or oxidized to carboxylic (-COOH).

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.

DOPE-PEG is a versatile phospholipid derivative with unique properties that make it suitable for various applications. Its hydrophobic and hydrophilic nature enables efficient encapsulation and delivery of drugs and nucleic acids, making it a valuable tool in drug delivery systems and gene therapy. Additionally, DOPE-PEG can enhance the stability and circulation time of liposomes, improving their efficacy as drug carriers.