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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC10413 DDP-38003 dihydrochloride
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.
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DC12593 DD-03-171
DD-03-171 is a small molecule, CGI1746-based BTK degrader (PROTAC, biochemical IC50=5.1 nM) that efficiently degrade C481S-BTK, exhibits enhanced anti-proliferative effects on mantle cell lymphoma (MCL) cells in vitro by degrading BTK, IKFZ1 and IKFZ3.
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DC24137 DCVC
DCVC (S-(1,2-dichlorovinyl)-L-cysteine) is an active metabolite of trichloroethylene.
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DC12055 DC1-SMe
DC1-Sme is an antibody conjugate of phosphate prodrug of cytotoxic DNA alkylators for the targeted treatment of cancer.
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DC12361 DC1
DC1, an analogue of the minor groove-binding DNA alkylator CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer.
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DC23976 DC_517
DC_05 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases.
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DC8108 DBPR108
DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. IC50 value: 15 Nm.
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DC21892 dBET23
dBET23 is a BRD4 heterobifunctional small-molecule ligand (PROTAC), exhibits significant and selective degradation of BRD4 BD1 (DC50/5h=50 nM) in cellular degradation assays..
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DC21987 DBCO-PEG4 amine
DBCO-PEG4 amine (ADIBO-PEG4-amine) is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC22076 DBCO-NHS ester 3
DBCO-NHS ester 3 (DIBAC-NHS) is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC20355 DBCO-NHS ester 2
DBCO-NHS ester 2 is a derivative of DBCO (Dibenzylcyclooctyne) used in Cu-free click chemistry.
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DC21891 DBCO Maleimide
DBCO Maleimide is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21889 DBCO intermidate 2
DBCO intermidate 2 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21888 DBCO intermidate 1
DBCO intermidate 1 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21886 DBCO acid 5
DBCO acid 5 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21885 DBCO acid 4
DBCO acid 4 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21884 DBCO acid 3
DBCO acid 3 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21883 DBCO acid 2
DBCO acid 2 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC21882 DBCO acid 1
DBCO acid 1 is a Click Chemistry intermidate used for antibody-drug conjugates..
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DC12517 HT105
DB550 (DB-550, TCWKHRK) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction, abrogates the CD95-mediated Ca2+ response in mouse PBLs with IC50 of 38 nM.
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DC12516 DB550
DB550 (DB-550) is a potent, peptidomimetic of calcium-inducing domain (CID) that disrupts the CD95-PLCγ1 interaction without affecting the CD95-FADD interaction binds to SH3-PLCγ1 with Kd of 40.7 uM.
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DC20943 DB2115
DB2115 is a small-molecule transcription factor PU.1 inhibitor abrogating DNA binding by PU.1 with Kd of 1.0 nM.
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DC22067 DB1055
DB1055 (DB-1055, DB 1055) is a small molecule inhibitor of HOXA9/DNA interaction through binding as minor groove DNA ligand on the HOXA9 cognate sequence.
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DC20942 DB04760
DB04760 is a potent, highly selective, non–zinc-chelating MMP-13 inhibitor with IC50 of 8 nM, displays high selectivity over other MMPs.
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DC9331 Daun02
Daun02 is a daunorubicin b-galactoside prodrug for use in conjunction.
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DC21381 Dasolampanel
Dasolampanel (NGX426) is an orally bioavailable, competitive antagonist of the AMPA-kainate receptors for the treatment of chronic pain conditions including neuropathic pain and migraine..
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DC3152 Darifenacin
Darifenacin is a selective M3 muscarinic receptor antagonist with pKi of 8.9.
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DC10259 Dapson
Dapsone, also known as diaminodiphenyl sulfone (DDS), is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy.
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DC20354 DAPH-12
DAPH-12 is a small molecule that directly inhibits and reverses prion protein Sup35 prionogenesis (IC50=0.18 uM).
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DC8665 Dantrolene sodium hemiheptahydrate
Dantrolene sodium hemiheptahydrate is a skeletal muscle relaxant which acts by blocking muscle contraction beyond the neuromuscular junction. Dantrolene sodium hemiheptahydrate is a inhibitor of calcium channel proteins, inhibiting the release of Ca2+ fro
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