Potent and selective M1 antimuscarinic

Natural antibacterial agent, being active against gram-positive bacteria.

Novel monocyte/macrophage targeted histone deacetylase inhibitor

Novel antimalarial agent

Novel inhibitor of the p53-Hdm2 protein-protein interaction, dose-dependently stabilized P53 and increased P21 and MDM2 expression in JAR choriocarcinoma cells, inducing the p53 regulated gene (PIG-3) and caspase activity

Novel potent inhibitor of tyrosyl-DNA phosphodiesterase 1 (Tdp1)

Novel Specific Copper Chelator, Reducing Memory Impairments in Alzheimer's Disease Mouse Models

Hepatotoxicity inducer, significantly up-regulating the expression of genes involved in endoplasmic reticulum stress and Toll-like receptor (TLR) pathway

Novel long-acting β 2 -adrenoceptor agonist

Novel potent BET protein degrader, inhibiting cell proliferation due to suppressed C-MYC transcription

Novel selective opioid receptor antagonist at all three receptor types

Novel IKZF1/3 degrader, inhibiting the proliferation of multiple myeloma cells in vitro as well as in vivo

Novel degrader of the anaplastic lymphoma kinase (ALK) fusion protein, effectively inducing ALK degradation and inhibiting the growth of ALK fusion positive cell lines, SU-DHL-1 and H3122, significantly reducing the tumor growth in H3122 xenograft model

Sorafenib analogue, retaining cytotoxicity similar to sorafenib in various human cancer cell lines and strongly inhibiting growth in the NCI-60 cell line panel

Potent equilibrative nucleoside transporter 4 (ENT4) inhibitor

Insulin receptor sensitizing agent; Selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B)

Novel GPR35 agonist

Novel potent and selective CHK1 kinase inhibitor

Potent and selective polo-like kinase 2 (PLK2) inhibitor

Nonpeptide partial agonist of oxytocin (OT) and vasopressin V2 receptors

Highly potent NR2B-selective NMDA receptor antagonist

Novel Inhibitor of the malaria parasite protein kinase CLK3, inhibiting the development of liver-stage parasites, killing asexual blood-stage parasites at the trophozoite and schizont stages of the erythrocytic cycle, blocking the development of sexual ga

Antimalarial; Novel inhibitor of HepG2

Potent TRPM8 antagonist, exhibiting antiallodynic properties in pain models

Non-competitive modulator of the proteasome inducing apoptosis a panel of myeloma and leukemia cell lines

Potent and selective antagonist of adenosine A2A receptors

Novel orally bioavailableγ-secretase modulator, reducing Aβ42 levels

Potent CB1 receptor inverse agonist

Aquaporin 1 (AQP1) channel blocker

Novel potent and selective ligand of Brd2(2)