Novel agonist for nicotinic acetylcholine receptors (nAChRs), modestly selectively targeting α6β2 subtype

Novel anti-angiogenesis and vascular disrupting agent, exhibiting moderate inhibitory cell proliferation activity

Novel anti-angiogenesis and vascular disrupting agent, exhibiting moderate inhibitory cell proliferation activity

Novel TBK1/IKKε inhibitor

Highly potent activator of Nrf2; Potent phase 2 cytoprotective pathway inducer and liver carcinogenesis blocker

Novel potent MCT1 inhibitor, exhibiting good single agent anticancer efficacy properties

Novel antibiotic against Mycobacterium tuberculosis (Mtb), potently killing replicating, virulent Mtb H37Rv in a clavulanate-dependent manner

Novel antagonist of IL-6 signaling

Selective mast-cell-stabilizing agent, inhibiting ozone-induced airway hyperresponsiveness

Potential neuroprotective agent, showing effects on cellular models of oxidative stress and neuroinflammation

Novel brain penetrant Cx43 hemichannel blocker

Trans-activator of transcription (TAT) peptide, increasing Hepta-histidine (7H) permeability into cells for treatment of iPS cell-derived neurons carrying Tau or APP mutations suppressed Tau phosphorylation

Novel potent, selective, and orally active CRTH2 antagonist

Potent and selective sphingosine 1-phosphate 1 (S1P1) receptor antagonist (IC50 = 7.8 nM)

Potent and orally active V 1B receptor antagonist with antidepressant and anxiolytic activities in rodents

Tubulin-binding dolastatin-15 analog, demostrating a wide spectrum of In Vivo antitumor activity

Novel selective norepinephrine reuptake inhibitor, displaying significant norepinephrine transporter (NET) inhibitory activity toward the serotonin or dopamine transporters

Potent P-glycoprotein (P-gp) inhibitor

ADAM-17 (TACE) and MMP inhibitor, sensitizing cancer stem cells to the lethal effects of 5-FU and blocking shedding of TNF-α from cell membranes

Novel potent Na V -targeting peptide, exhibiting significant increased potency for Na V 1.1, Na V 1.2, Na V 1.3, Na V 1.6 and Na V 1.7 involved in several neurological disorders including acute and chronic pain, motor neuron disease and epilepsy

Novel potent Na V -targeting peptide, exhibiting significant increased potency for Na V 1.1, Na V 1.2, Na V 1.3, Na V 1.6 and Na V 1.7 involved in several neurological disorders including acute and chronic pain, motor neuron disease and epilepsy

Novel angiogenesis stimulator, promoting multiple key steps of angiogenesis parially via Akt and MAPK signalling pathways, showing anti-ischemic and anti-atherosclerosis activities, also acting as a putative PPARγ agonist

Potent and selective non-peptide δ1 opioid receptor agonist

Novel Fluorescent dATP for DNA Synthesis In Vivo, exhibited high brightness, low toxicity, and rapid incorporation and depletion kinetics in both a vertebrate (zebrafish) and a nematode (Caenorhabditis elegans)

Superagonist at the human thyrotropin-releasing hormone receptor, reversing opioid-induced respiratory depression in isoflurane anesthetized rats

Novel Antibody-Drug Conjugate PBD Dimer Payload

Natural neurotrophic agent, promoting neurite outgrowth from neurons through PI3K/Akt pathway

CYP26 inhibitor, potentiating the effects of all-trans retinoic acid on cultured human epidermal keratinocytes

Natural ferroptosis inducer, killing colorectal cancer cells in vitro and in vivo

Novel inhibitor of the epigenetic modulator lysine-specific demethylase 1A (LSD1)