Acetyl hexapeptide-1 (Melitane) is a bioactive peptide with anti-wrinkle effect and has been reported used as a cosmetic ingredient.

cyclo(-RGDfK,-Arg-Gly-Asp-D-Phe-Lys)) is a selective αvβ3-integrin antagonist.

Antiviral activity against Varicella Zoster

Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a fluorogenic substrate for matrix metalloproteinase-1 (MMP-1) and MMP-9

Novel BRD4 inhibitor, suppressing osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL-mediated MAPK and NF-κB pathways

Natural highly potent inhibitor of the serotonin transporter (SERT)

Novel TNKS/2 inhibitor, competing with nicotinamide binding to tankyrases

Lemborexant (E-2006) is a dual antagonist of the orexin OX1 and OX2 receptors which is under development for treatment of insomnia.

PF-07220060 is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.

Natural inhibitor of ERK signaling pathways, inhibiting epithelial-mesenchymal transition via STAT3, showing the growth inhibition of HepG2, HeLa and MGC-803 cancer cell lines

Natural inhibitor of hepatocyte ferroptosis, protecting against drug-induced liver injury

Novel non-nucleoside reverse transcriptase inhibitor (NNRTI)

Inhibitor of VMAT-2, decreasing monamines into synaptic vesicles

Novel potent inhibitor of the CREBBP/EP300 bromodomain, showing >100-fold selectivity over a representative member of the BET bromodomains, BRD4(1)

BAY-9835 is the first orally bioavailable ADAMTS7 inhibitor with IC50 of 6 nM, which is selective against a range of off-targets and metalloproteases except for ADAMTS12.

Natural modulator of miRNA biogenesis, inhibiting the proliferation, migration, and invasion of hepatocellular carcinoma (HCC) cells

Subtype-selective activator of K(Ca)2.1

MM 07 is a biased apelin receptor agonist, with a KD of 300 nM in CHO-K1 cells and a KD of 172 nM in human heart.

AAcid-PEG5-C2-Boc is a PEG derivative containing a t-butyl protected carboxyl group with a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Novel inhibitor of cholesterol transport proteins

Antitumor agent to be associated with negative regulation of Met endosomal signaling in renal cancer cells

Inhibitor of Eukaryotic Translation; Antitumor Natural Product

Moderate alpha-l-fucosidase inhibitor

Natural microbial metabolite of isoflavone genistein, increasing the lifespan and improving the thermal and oxidative stress tolerance of C. elegans

Less active enantiomer of Elexacaftor

BAY-805 is a potent and selective USP21 inhibitor. BAY-805 is a non-covalent inhibitor with low nanomolar affinity for USP21 and high selectivity over other DUB targets as well as kinases, proteases, and other common off-targets.

Metabolite of VX-740

Vesicular monoamine transporter-2 (VMAT2) inhibitor, with 15-​fold greater affinity than GZ-​793A

Inactive control for VinSpinIn