Natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro

Novel antagonist against hypocretin (orexin) receptor 2, significantly preventing acute morphine-conditioned place preference (CPP) and stress-induced reinstatement of extinguished morphine-CPP in mouse models of opioid reward and relapse

Selective long-acting beta2-adrenergic agonist (LABA) with inherent 24-hour activity for once daily treatment of COPD and asthma

Broad spectrum antibiotic, inhibiting adenylyl cyclase type 5 (AC5) and protecting against chronic coronary artery occlusion (CAO)

Clopidogrel analog as an antiplatelet agent

Natural protein kinase C (PKC) activator and HSP90 inhibitor, sensitizing human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn

The first sub-micromolar inhibitor of the VHL-HIF1α interaction

Novel Inhibitor of the Pro-Angiogenic Activity of the Zinc Finger Transcription Factor Vezf1

Novel anti-vesiculoviral agent, inhibiting transcription initiation of vesiculoviruses

Potent inhibitor of acetylcholine transport

Apoptosis inducer, inhibiting Leiomyosarcoma and Malignant peripheral nerve sheath tumor growth

Natural insect ryanodine receptor (RyR) antagonist

Natural Reversible Plant Growth Inhibitor

Novel blocker of atrial potassium channels

Natural anti-inflammatory and antioxidant agent, inhibiting both iNOS expression and NO release in the LPS-induced J774.A1 macrophage cell line, enhancing protein expression levels of PARP-1 and p53, and attenuating intracellular ROS and stress (oxidative

Natural Janus-Faced Modulator of Voltage-Gated Sodium Ion Channels, acting on the channel as either an agonist or antagonist depending on the nature of the electrophysiological stimulation protocol

Antitumor agent

Serotonin-norepinephrine reuptake inhibitor (SNRI); Antidepressant

Activator for Proprietary Gene Therapy Promoter System

Potent, Vascular Endothelial Growth Factor Receptor-​2 (VEGFR-2) Tyrosine Kinase Inhibitor

Novel Aurora kinase inhibitor

Novel nonsecosteroidal vitamin D receptor (VDR) modulator, enhancing pancreatic cancer therapy through remodeling of the tumor microenvironment by combination with gemcitabine

Novel nonsecosteroidal vitamin D receptor (VDR) modulator, enhancing pancreatic cancer therapy through remodeling of the tumor microenvironment by combination with gemcitabine

Novel nonsecosteroidal vitamin D receptor (VDR) modulator, enhancing pancreatic cancer therapy through remodeling of the tumor microenvironment by combination with gemcitabine

Novel potent and selective CA IX inhibitor

Novel potent and selective CA IX inhibitor

Novel selective inhibitor of the γ-class enzyme of bacteria Vibrio cholerae A (VchCAγ)

Novel non-nucleoside inhibitor of HCV RNA-dependent polymerase

Novel inhibitor of VDAC1 oligomerization and apoptosis

Novel potent inhibitor of VDAC1, directly interacting with purified VDAC1 and reducing its channel conductance