The first potent and selective inhibitor of human nucleoside triphosphate diphosphohydrolase-2 (NTPDase2)

Fluorescent Probe for Ecto-5'--nucleotidase (CD73)

Novel Potent Agonist of the Orphan G Protein-Coupled Receptor GPR17 (EC 50 32.1 nM)

Novel Potent Agonist of the Orphan G Protein-Coupled Receptor GPR17 (EC 50 27.9 nM)

Fluorescent Probe for Ecto-5'--nucleotidase (CD73)

Novel potent and selective agonist of the orphan G protein-coupled receptor 84 (GPR84)

Novel Potent Agonist of the Orphan G Protein-Coupled Receptor GPR17 (EC 50 12 nM)

Novel Potent and Selective Antagonist for the UTP-Activated P2Y4 Receptor

Novel potent Lp1NTPDase inhibitor

Highly potent, selective, competitive, and reversible inhibitor of monoamine oxidase B (MAO-B)

Novel fluorescent-labeled selective adenosine A2B receptor antagonist

Potent competitive antagonist and positive modulator of the P2X2 receptor

Positive modulator of ATP effects at P2X2 receptors

Potent competitive antagonist and positive modulator of the P2X2 receptor with >100-fold selectivity versus P2X4, P2X7, and several investigated P2Y receptor subtypes (P2Y(2,4,6,12))

Unique inhibitor of bacterial chromosomal partitioning, increasing the efficacy of bortezomib and sorafenib through regulation of stress granule formation

Naturally occurring inhibitor of FOXO1a nuclear export

Highly potent and selective VDR-coactivator inhibitor

Novel inhibitor of upstream IκB kinase (IKK), specifically inhibiting the IκB phosphorylation and degradation and the subsequent nuclear translocation of NF-κB

Novel selective 5-HT6 receptor antagonist, enhancing cognition and memory and potently decreasing food intake and body weight in rodents

Selective 5-HT4 agonist

Novel potent and selective inhibitor of SETD2

Novel selective CB2 agonist (CB2: 17.4 nM and CB1: 5585 nM)

Novel bacterial polyyne contributing to the antioomycete and plant-protective effects of P. protegens

Novel PROTAC, targeting steroid hormone receptors for ubiquitination and degradation

The most potent and selective ERRα degrader

Novel selective and potent Fak degrader

Novel SirReal-based PROTAC, inducing isotype-selective Sirt2 degradation, resulting in the hyperacetylation of the microtubule network coupled with enhanced process elongation

Proteolysis targeting chimeras (PROTAC), providing broad tissue distribution and knockdown of the targeted RIPK2 protein in tumor xenografts

Proteolysis targeting chimeras (PROTAC), providing broad tissue distribution and knockdown of the targeted ERRalpha protein in tumor xenografts

Novel potent degrader of H-PGDS protein via the ubiquitin-proteasome system and in the suppression of prostaglandin D2 (PGD2) production