Second-Generation GluN2C- and GluN2D-selective positive allosteric modulator (PAM) of the N-methyl-d-aspartate (NMDA) receptor

Novel microtubule destabilizer

Novel antivirulence agent against Vibrio vulnificus, inhibiting the quorum-sensing signaling pathway by controlling the DNA-binding affinity of SmcR and thus effectively alleviating the virulence of V. vulnificus in vitro and in vivo

Natural disrupter of DNA replication and transcription via DNA intercalation, reducing oxygen intake and carbohydrate metabolism and the excitability of muscle fibers, inhibiting the drug efflux pump P-glycoprotein

Potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor

Modulator of specific GABAA receptors via the benzodiazepine site on the GABAA receptor

Novel photodynamic antitumor agent

Novel multitarget anti-AD agent, significantly increasing in adult neurogenesis and remyelination through Prox1/NeuroD1 and Wnt/β-catenin pathways, demonstrating beneficial effects in preclinical models of AD

Novel potent inhibitor of quorum sensing (QS) pathways, strongly blocking agr-type QS in S. aureus

Novel potent inhibitor of quorum sensing (QS) pathways, strongly blocking agr-type QS in S. aureus

Novel fluorescent molecular rotor for the selective detection of the hybrid-conformation 22AG G-Quadruplex

Novel Nav1.7 channel blocker (IC 50 at 3.5±1.5 μM). being efficacious on chronic pain in mice

Novel reactive oxygen species (ROS) inducer, showing significant cytotoxicity in pancreatic cancer cells

Novel Heme Oxygenase-1 Inhibitor (HO-1 IC 50 =0.27μM; HO-2 IC 50 =0.46μM)

Selective PAR1 negative allosteric modulator

Novel class of bright near infrared window II (NIR-II, 1,000 - 1,700 nm) probe, being successfully used to achieve high spatial and temporal resolution imaging of hind limb vasculature, lymphatic system, and small tumor metastasis, as well as precise NIR-

Novel inverse agonist of 5-HT6 receptor

Y2/Y5 Neuropeptide Y receptor agonist, reducing food intake in normal-weight and obese individuals and the plasma levels of the hunger-promoting hormone ghrelin

Novel BBB-permeable substrate of pyrilamine-sensitive proton-coupled organic cation antiporter (PYSOCA), acting as a selective class I HDAC inhibitor

Novel KMD5A inhibitor

Novel highly potent agonist of the apelin receptor (APJ) receptor (APJ cAMP EC50: human 0.023nM; rat 0.024nM; dog 0.030nM; monkey 0.080nM)

Natural phytotoxin, inducing monopolar spindle formation and suppressing proliferation of cancer cells

Novel inhibitor of the PyrD protein (a dihydroorotate dehydrogenase (DHODase) involved in pyrimidine biosynthesis), suppressing bacterial cytotoxicity, biofilm formation and antibiotic resistance

Novel inhibitor of p53-MDM2 interaction

Bacterial siderophore, acting as an iron-chelating growth promoter for Pseudomonas aeruginosa

Novel suppressor of cancerous cell growth and proliferation

Novel potent inhibitor of collagen prolyl-4-hydroxylases (CP4H)

Inhibitor of cell death induced by oxidative stress and inhibitor of AB1-40 aggregation induced by Cu2+ ion

Novel selective FGF14:Nav1.6 PPI modulator

Novel Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitor