Novel food intake-reducing agent

Potent and specific integrin α4ß1 or very late antigen 4 (VLA-4) receptor antagonist, binding to vascular cell adhesion molecule-1 (VCAM-1) and fibronectin

Potent inhibitor of nicotinamide phosphoribosyltransferase (Nampt)

Irriversible inhibitor of GSK3

Protein kinase C partial agonist, targeting the C1 domain, inhibiting cell proliferation, decreasing cell viability and inducing an apoptotic response

Potent stimulator of gamma delta T cells

Novel highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action (IC 50 = 42 nM; SI > 2375)

Novel antagonist to the inhibitors of apoptosis (IAPs), potentiating cell death in EGFR-overexpressing non-small-cell lung cancer cells

Potent and highly selective FABP4 inhibitor

Novel Nerve Agent Reactivator

First-in-class inhibitor of protein arginine methyltransferase 5 (PRMT5)

Novel phosphoramidate prodrug of ddhCTP, effectively reducing titers of Zika and West Nile viruses in cell culture with minimal nonspecific toxicity to host cells

Selective Acetylcholinesterase Inhibitor

Novel SARS-CoV-2 Main Protease (Mpro) inhibitor, binding to Subsites S1 and S2 (K d =0.69 µM)

Novel Metformin Derivative; Inhibitor of Proliferation and Invasion of Triple-Negative Breast Cancer Cells

Novel allosteric hexokinase 2 (HK2) modulator, selectively detaching HK2 from the mitochondria

Novel inhibitor of YycG histidine kinase (HK), showing potent antibiofim activity against Staphylococcus epidermidis

Novel apigenin analogue, suppressing pancreatic stellate cell proliferation

Novel potent orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3)

Novel orally bioavailable STAT3 inhibitor

AMPA Receptor Positive Allosteric Modulator

Novel highly potent HIV-1 inhibitor with broad-spectrum activity (EC50 = 2.0-57 nM) against resistant strains, exhibiting good solubility and safety profiles and a good PK profile with an oral bioavailability of 59% in rats

Novel photoaffinity-labeled probe for full-length human immunodeficiency virus-1 integrase (HIV-1 IN)

Novel enhancer of catalytic efficiency of neurolysin

Novel enhancer of catalytic efficiency of neurolysin

Allosteric inhibitor of ATP phosphoribosyltransferase (ATPPRT), binding to the ATPPRT:ATP complex via a two-step binding mechanism, inhibiting ATPPRT competitively and likely uncompetitively, respectively, against PRPP and ATP

Natural alkaloid, demonstrating significant cytotoxicity against a panel of human and murine tumor cell lines

Novel Potent Inhibitor of HIPK1/HIPK2 Kinase

Natural muscarinic receptor antagonist

Novel HIF Pathway Inhibitor