Pathogen motility inhibitor of EcDsbA

Novel Potent, Orally Available G9a/GLP Inhibitor for Treating β-Thalassemia and Sickle Cell Disease

Novel potent orally active hepcidin production inhibitor

Novel non-macrolide GPR38 agonist

Novel and orally bioavailable PTHR1 antagonist

Novel potent orally active hepcidin production inhibitor

Novel selective PPARγ modulator, resulting in robust plasma glucose reductions with excellent DMPK profiles

Novel potent PTHR1 antagonist

Inhibitor of the growth of estrogen receptor-presenting breast cancers

Oral non-opioid anti-tussive agent for treatment of cough

Novel inhibitor of the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV

Novel inhibitor of the interaction of hACE2 with the spike proteins of SARS-CoV-2 as well as SARS-CoV

Novel Dual PROTAC for Simultaneous Degradation of EGFR and PARP

Click chemistry tool molecule in probing peptidoglycan (PG)

Novel DprE1 inhibitor, killing M. tuberculosis

Substrate of CYP3A and inhibitor of P-glycoprotein

Novel selective DPP8/9 inhibitor, blocking AML progression in vivo

Novel inhibitor of dipeptidyl peptidase 7 (DPP7)

Novel highly selective agonist for the δ-opioid receptor, producing less convulsions than most drugs from this family and having antidepressant-like effects

First Potent Small Molecule Ligand for MALAT1

Novel Dual PROTAC for Simultaneous Degradation of EGFR and PARP

Novel boron-containing dopa-derivative, acting as a bladder relaxant through non-catecholamine receptors

Novel 2-aminoethyl diphenylborinate (2-APB) analogue, inducing a profound activation of SOCE in DT40 cells, albeit at low concentrations (10 nM), blocking the melatonin-induced [Ca ] cyt increase and SOCE in P. falciparum.

Novel effective and selective inhibitor of E. coli topoisomerase I

Novel antibacterial with activity against the Gram-negative bacteria associated with nosocomial infections

Agonist of GABAA receptors α15 subunits

Tricyclic antidepressant (TCA), acting as a serotonin–norepinephrine reuptake inhibitor (SNRI) and also having other activities including antihistamine, antiadrenergic, antiserotonergic, anticholinergic, and sodium channel-blocking effects

Anthelmintic, for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle

Dual orexin receptor antagonist (OX1R and OX2R antagonist or DORA)

Selective MAO-B inhibitor