Analeptic agent, stimulating central nervous system; Anti-barbiturate-overdose

Novel antitubercular and antiparasitic agent, possessing excellent in vitro activity against both L. donovani and Leishmania infantum as well as displaying a better safety profile

Novel potentiator of β-lactam activity against Gram positive and Gram negative pathogens

Novel DNA primase inhibitor

Novel DNA primase inhibitor

Novel,orally active and selective alpha-7 nicotinic acetylcholine (nACh) receptor

Potent and highly selective µ opioid agonist

Novel inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Novel cell permeable caged Luciferin

Novel potent and selective PROTAC degrader of myeloid cell leukemia 1 (MCL1)

Novel non-nucleoside inhibitor of Zika viral RNA-dependent RNA polymerase (RdRp) enzymes

Novel blocker of the TLR2 and TLR4 downstream signaling pathway, effectively inhibiting mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB

Novel antineoplastic agent, exhibiting remarkable anticancer activity as well as excellent cellular selectivity

Novel multi-target anticancer prodrug activated by the tumor specific CYP1B1 enzyme, potently inhibiting HCT-15, HCT-116 and K562 cells growth, showing moderate anti-proliferative activity towards MDA-MB-231, HepG2, PANC, Bel7402 and MGC803 cancer cells,

Prodrug of CPPTL, inducing apoptosis in a dose-dependent manner via the ROS/JNK pathway in acute myeloid leukemia

Chromogenic peptide substrate, being highly sensitive for the measurement of activated Protein C.

Ultrasensitive bioluminogenic enzyme substrate

Competitive inhibitor of both SPHK1 and SPHK2

Specific protein disorder catalyzer of HIV-1 Nef

Novel potent anti-MRSA agent, disrupting biofilms with no resistance development, sensitizing rifampicin and tetracycline against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa

Novel acetylcholinesterase inhibitor, promoting synaptic function and neuronal survival, ameliorating cognitive deficits in SAMP8 mice via improved mitochondrial dynamics and increased activity of the NMDAR-CREB-BDNF pathway

Novel autophagonizer, inducing autophagic cell death in apoptosis-defective cell line

Inhibitor of NF-kappaB-mediated GROalpha expression, suppressing the TNFalpha-induced invasive capability of MDA-MB-231 human breast cancer cells

Novel inducer of apoptotic cell death in TNBC cell lines without causing cytotoxicity in the normal mammary epithelial cell line

Novel inducer of apoptotic cell death in TNBC cell lines without causing cytotoxicity in the normal mammary epithelial cell line

Novel selective Factor Xa inhibitor, reducing thrombus formation with low risk of bleeding

Parasympathomimetic with longer duration of action

Antibiotic, specifically inhibiting the initiation of RNA synthesis, binding isohelically to the minor groove of B-DNA at A/T rich sites

Inhibitor of ATPase activity of HSP70

Novel negative allosteric modulator of the mGlu5 receptor