Novel r(CUG) repeat expansion cleaver, specifically recognizing the 3-dimensional structure of r(CUG)exp, cleaving it more selectively among transcripts containing short, nonpathogenic r(CUG) repeats than an oligonucleotide that recognizes RNA sequence vi

Novel fluorescent RXR agonist

Novel Serotonin 5-HT 2C Receptor Positive Allosteric Modulator (PAM) with Enhanced Drug-like Properties

Inhibitor of prostate-specific membrane antigen (PSMA)

Novel anticancer agent, effectively killing multi-drug resistant cancer cells and a panel of different cancer cells originated from a variety of different tissues including breast and skin, preventing tubulin polymerization, leading to the cell cycle arre

Novel anticancer agent, effectively killing multi-drug resistant cancer cells and a panel of different cancer cells originated from a variety of different tissues including breast and skin, preventing tubulin polymerization, leading to the cell cycle arre

Novel cell permeable degrader of BRD4

Novel potent dual inhibitor of ALK and c-Met

Dual inhibitor of angiogenesis and lysophosphatidic acid acyltransferase

Novel G9a (EHMT2) inhibitor, binding tightly inside the active site cavity of G9a, inhibiting the activity of G9a in both enzyme and cell based assays with much lesser toxicity than BIX-0129

Novel substrate-competive c-Src inhibitor

Novel modulator of PI3K and NF-κB activities, blocking migration and production of inflammatory mediators

Novel photoisomerizable potent and selective M1 ligand, mimicing the tricyclic chemical structure and display reversibly controlled activity, showing stronger inhibition upon illumination both in vitro and in cardiac atria ex vivo

Inhibitor of gene products associated with cell survival, proliferation, invasion, and angiogenesis, targeting NF-κB pathway, showing antiproliferative activity and unique mode of action

Novel water-soluble, potent, and selective TRPM8 receptor agonist

Novel TRPM8 agonist

Novel potent powerful lipid A analogue as a conjugation-ready TLR4 ligand

TLR4 antagonist, protecting against advanced diabetic nephropathy

Potent and selective CRTH2 antagonist

Potent and selective inhibitor of AKR1C3

Potent and selective inhibitor of AKR1C3

Novel potent and mycobacteria-specific antimycobacterial agent, targeting MmpL3, a mycobacterial mycolic acid transporterr, demonstrating MIC = 0.03, 2, and ≤ 0.12 μg/mL against Mabs, Mycobacterium avium complex (MAC), and Mtb respectively

Novel potent and mycobacteria-specific antimycobacterial agent, targeting MmpL3, improving the antimycobacterial activity and being also potent against Mtb

Novel potent, selective, and reversible inhibitor of human monoamine oxidase B (hMAO-B)

Novel potent, selective, and reversible inhibitor of human monoamine oxidase B (hMAO-B)

Selective dopaminergic reuptake inhibitor

Antineoplastic and Antibacterial; Inducer of death in cancer cells through a reactive oxygen species (ROS)-mediated mechanism; Dark blue cancer cell growth inhibitor

Natural antiangiogenic homoisoflavanone, inhibiting the proliferation, migration and tube formation ability of human retinal microvascular endothelial cells

Novel CREBBP Bromodomain Inhibitor

Novel potent and cell-permeable inhibitor of cAMP-response element binding protein (CREB)