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Cat. No. Product Name Field of Application Chemical Structure
DC49205 Calcium glycerophosphate
Calcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3. Calcium glycerophosphate is a source of calcium and phosphorus in total parenteral nutrition solutions.
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DC49204 L-Serine-15N
L-Serine-15N ((-)-Serine-15N) is the 15N-labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation.
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DC49203 Sarcosine-15N
Sarcosine-15N (N-Methylglycine-15N) is the 15N-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia.
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DC49202 β-Alanine-15N
β-Alanine-15N (2-Carboxyethylamine-15N) is the 15N-labeled β-Alanine. β-Alanine is a non-essential amino acid that is shown to be metabolized into carnosine, which functions as an intracellular buffer.
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DC49201 Zaragozic acid B
Zaragozic acid B, a fungal metabolite, is a potent inhibitor of both farnesyl-protein transferase (FPTase) and squalene synthases. Zaragozic acid B is a potential anticancer drug.
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DC49200 p-fin4
p-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators.
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DC49199 UNC6212 (Kme2)
UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a KD for CBX5 of 5.7 μM.
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DC49198 Biotinylated-JQ1
Biotinylated-JQ1 (Biotin-JQ1) is a biotinylated derivative of JQ1 with high affinity for BRD4.
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DC49197 PROTAC BRD9 Degrader-2
PROTAC BRD9 Degrader-2 is a BRD9 bifunctional degrader for treating cancer.
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DC49196 Pomalidomide-C5-Dovitinib
Pomalidomide-C5-Dovitinib (compound 2) is a PROTAC containing Pomalidomide, Dovitinib and connected with CRBN. Pomalidomide-C5-Dovitinib shows enhanced antiproliferative effects against FLT3-ITD+ AML cells. Pomalidomide-C5-Dovitinib induces the degradation of the FLT3-ITD and KIT proteins in a ubiquitin-proteasome-dependent manner and completely blocks their downstream signaling pathway. Pomalidomide-C5-Dovitinib has the potential for the research of FLT3-ITD+ acute myeloid leukemia.
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DC49195 m-PEG18-acid
m-PEG18-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49192 18:1 Ethylene Glycol
18:1 Ethylene Glycol is a liposome used to deliver drugs.
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DC49191 Trichodecenin II
Trichodecenin II is a fungal metabolite that can be found in conidia of the fungus, Trichoderma viride.
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DC49190 Trichodecenin I
Trichodecenin I, a fungal metabolite, is a peptaibol composed of 7 amino acid residues.
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DC49189 Con B-1
ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells.
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DC49188 EGFR-IN-22
EGFR-IN-22 is a potent EGFR inhibitor with IC50s of 4.91 nM and 0.54 nM for wild type EGFR and EGFRL858R/T790M/C797S, respectively (CN112538072A, compound 243).
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DC49187 Acetyl podocarpic acid anhydride
Acetyl podocarpic acid anhydride is a potent, semisynthetic liver X receptor(LXR) agonist derived from extracts of the mayapple. Acetyl podocarpic acid anhydride has the potential to be useful for the prevention and treatment of atherosclerosis, especially in the context of low HDL levels.
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DC49186 Phainanoid A
Phainanoid A is a unique dammarane-type triterpenoid.
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DC49185 P-BP-SFAC
P-BP-SFAC is a fluorescence molecule. P-BP-SFAC exhibits an apparent absorption band with a peak at about 377 nm, indicative of a stronger ICT effect.
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DC49184 t-Boc-N-amido-PEG15-Br
t-Boc-N-amido-PEG15-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49183 Biotin-PEG10-NHS ester
Biotin-PEG10-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49182 TC113
TC113 is a c(RGDyK)-Based conjugate of Gemcitabine (GEM). TC113 could be internalized by A549 cells through integrin αvβ3. TC113 shows potent antiproliferative properties against WM266.4 and A549 cells.
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DC49181 Hydroxy ritonavir
Hydroxy ritonavir is a metabolite of Ritonavir. Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
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DC49180 Anticancer agent 25
Anticancer agent 25 exhibits the strongest cytotoxicity against PC3 cells with an IC50 value of 0.19 μM.
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DC49179 YS-370
YS-370 (compound 44) is a potent, high selective, and orally active inhibitor of P-glycoprotein (P-gp). YS-370 stimulates the P-gp ATPase activity and has moderate inhibition against CYP3A4. YS-370 effectively reverses multidrug resistance (MDR) to paclitaxel and colchicine in SW620/AD300 and HEK293T-ABCB1 cells. YS-370 in combination with paclitaxel achieves much stronger antitumor activity.
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DC49178 HO-PEG18-OH
HO-PEG18-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49177 1,2-DImyristoyl-rac-glycero-3-phosphocholine
1,2-DImyristoyl-rac-glycero-3-phosphocholine (DMPC), a zwitterionic phospholipid, is chosen as a simple eukaryotic cell membrane, mimicking the neutral charge of the surface membrane of eukaryotic plasma membranes.
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DC49176 Acid-PEG14-t-butyl ester
Acid-PEG14-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49175 MC-Val-Cit-PAB-NH-C2-NH-Boc
MC-Val-Cit-PAB-NH-C2-NH-Boc is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC49174 Phytochelatin 4 TFA
Phytochelatin 4 (PC 4) TFA is a short Cys-rich peptide with repeating γ-Glu-Cys motifs found in plants.
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