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| Cas No.: | 175735-93-0 |
| Chemical Name: | alpha-conotoxin MII |
| Synonyms: | alpha-conotoxin MII;alpha-MII;MII;α-conotoxin MII;α-CTxMII |
| SMILES: | N12C(=O)C(C(C(=O)N([H])[H])([H])[H])([H])N([H])C(=O)C(C(O[H])([H])[H])([H])N([H])C(=O)C3(C(SSC(C(N(C(C(N(C(C(N(C(C(N(C(C(N(C(C(N(C(C(N(C(C(N(C(=O)C(C(SSC(C(C(N3[H])=O)(N(C(C(N([H])[H])([H])[H])=O)[H])[H])([H])[H])([H])[H])([H])N([H])C(=O)C(C(C([H])([H])[H])(C([H])([H])[H])[H])([H])N([H])C(=O)C1(C(C(C2([H])[H])([H])[H])([H])[H])[H])[H])(C(c1nc([H])[n]([H])c1[H])([H])[H])[H])=O)[H])(C(C(C([H])([H])[H])(C([H])([H])[H])[H])([H])[H])[H])=O)[H])(C(C(C(O[H])=O)([H])[H])([H])[H])[H])=O)[H])(C(c1nc([H])[n]([H])c1[H])([H])[H])[H])=O)[H])(C(O[H])([H])[H])[H])=O)[H])(C(C(=O)N([H])[H])([H])[H])[H])=O)[H])(C(C(C([H])([H])[H])(C([H])([H])[H])[H])([H])[H])[H])=O)[H])(C(=O)N([H])[H])[H])([H])[H])([H])[H])[H] |
| Formula: | C67H103N23O22S4 |
| M.Wt: | 1710.94 |
| Purity: | >98% |
| Sotrage: | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Description: | α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuronal nicotinic receptors. Displays > 200-fold selectivity for α3β2 over α2β2, α4β2 and α3β4. |
| Target: | IC50: 0.5 nM (α3β2)[1]. |
| In Vitro: | α-Conotoxin MII (0.5-3.5 nM) blocks ACh responses in oocytes expressing α3β2 nicotinic acetylcholine receptors[1][2]. |
| References: | [1]. G E Cartier, et al. A New Alpha-Conotoxin Which Targets alpha3beta2 Nicotinic Acetylcholine Receptors. J Biol Chem. 1996 Mar 29;271(13):7522-8. [2]. S C Harvey, et al. Determinants of Specificity for Alpha-Conotoxin MII on alpha3beta2 Neuronal Nicotinic Receptors. Mol Pharmacol. 1997 Feb;51(2):336-42. [3]. J M McIntosh, et al. Conus Peptides: Novel Probes for Nicotinic Acetylcholine Receptor Structure and Function. Eur J Pharmacol. 2000 Mar 30;393(1-3):205-8. |
MSDS
| TITLE | DOWNLOAD |
| MSDS_24816_DC41803_175735-93-0 |
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COA
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