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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC49103 NCGC00138783
NCGC00138783 selectively blocks the CD47/SIRPα interaction with an IC50 value of 40 μM for the cell surface binding. NCGC00138783 does not disrupt its binding to other receptors.
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DC49102 Gymconopin C
Gymconopin C shows an antiallergic effect on ear passive cutaneous anaphylaxis reactions in mice.
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DC49101 Morelloflavone
Morelloflavone has antioxidative, antiviral, and anti-inflammatory properties.
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DC49100 Tetracosactide acetate
Tetracosactide acetate is a synthetic peptide stimulating the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
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DC49099 Aluminum Glycinate
Aluminum Glycinate, an organo-metallic compound, is an antacid. Aluminum Glycinate can be used for the research of indigestion, acid reflux and ulcers.
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DC49098 t-Boc-Aminooxy-PEG11-amine
t-Boc-Aminooxy-PEG11-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49097 Biotin-PEG6-NH-Boc
Biotin-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49095 ABL-L
ABL-L induces apoptosis of human laryngocarcinoma cells through p53-dependent pathway.
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DC49094 Digoxigenin monodigitoxoside
Digoxigenin monodigitoxoside is a Na+/K+ ATPase inhibitor and cardiac glycoside metabolite of digoxin.
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DC49093 ent-Heronamide C
ent-Heronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C.
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DC49092 16,17-Dihydroheronamide C
16,17-Dihydroheronamide C has antifungal activity and is designed as probe for the mode-of-action analysis of heronamide C.
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DC49091 (S)-(-)-MRJF22
(S)-(-)-MRJF22 is haloperidol metabolite II valproate ester. (S)-(-)-MRJF22 exhibits the high antimigratory effects in endothelial and tumor cells. (S)-(-)-MRJF22 is a potential multifunctional agent against uveal melanoma.
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DC49090 Setosusin
Setosusin ((+)-Setosusin) is a fungal meroditerpenoid featuring a unique spiro-fused 3(2H)-furanone moiety.
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DC49089 Cyanosafracin B
Cyanosafracin B is a starting material for synthesis of Ecteinascidin ET-743 and Phthalascidin Pt-650.
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DC49088 EGFR-IN-26
EGFR-IN-26 is a EGFR inhibitor extracted from patent WO2019162323A1 compound I-028. EGFR-IN-26 can be used for the research of cancer.
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DC49087 KRAS G12C inhibitor 26
KRAS G12C inhibitor 26 is a KRAS G12C inhibitor with antitumor effects (WO2021109737).
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DC49086 KRAS G12C inhibitor 27
KRAS G12C inhibitor 27 is a KRAS G12C inhibitor with antitumor effects (WO2021109737).
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DC49085 Bafrekalant
Bafrekalant is a diazabicyclic substituted imidazo[l,2-a]pyrimidine-derivative. Bafrekalant has the potential for the research of breathing disorders, including sleep-related breathing disorders such as obstructive and central sleep apnea and snoring (extracted from patent WO2018228907A1).
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DC49084 Lubabegron
Lubabegron is a potent modulator of β-adrenergic receptor (β -AR). Lubabegron demonstrates antagonistic behavior at the β1 and β 2 receptor subtypes and agonistic behavior at the β 3 receptor subtype in cattle. Lubabegron reduces NH3 gas emissions from an animal or its waste.
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DC49083 PROTAC-O4I2
PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 (SF3B1). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells.
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DC49081 RET-IN-5
RET-IN-5 is a potent RET (rearranged during transfection) inhibitor with an IC50s of 0.4 nM and 135.1 nM for RET and VEGFR2, respectively (WO2021213476A1, compound 18).
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DC49080 ER 50891
ER-50891 is a potent antagonist of retinoic acid receptor α(RARα). ER-50891 significantly attenuates ATRA's inhibitive effects on BMP 2-induced osteoblastogenesis.
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DC49079 Acid-PEG10-t-butyl ester
Acid-PEG10-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49078 Phytochelatin 3 TFA
Phytochelatin 3 (PC 3) TFA is the small metal chelating peptide that can be used for chelating heavy metals.
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DC49077 Aszonapyrone A
Aszonapyrone A is a metabolite produced by Aspergillus zonatus.
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DC49076 Chevalone C
Chevalone C, a meroterpenoid fungal metabolite, shows antimalarial activity with IC50 value of 25.00 μg/mL. Chevalone C has anti-proliferative activity on colon HCT116, liver HepG2 and melanoma A375 cancer cell lines.
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DC49075 Calpain-2-IN-1
Calpain-2-IN-1 is a calpain-2 selective inhibitor that enhances learning & memory by prolonging ERK activation.
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DC49074 Derquantel
Derquantel is a potent anthelmintic. Derquantel causes flaccid paralysis and expulsion of nematodes.
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DC49073 Ablukast
Ablukast (Ro 23-3544) is a specific and active leukotriene receptor antagonist. Ablukast effectively reduces LTC4- and antigen-induced bronchoconstriction. Ablukast is LTD4 receptor antagonist.
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DC49072 Anticancer agent 28
Anticancer agent 28 showed good antitumor activity in H22 allogeneic mice in vivo. Its potency in K562 cells was 50 times that of oridonin, and its < b > IC < sub > 50 < / sub > < / b > value was 0.09 μ M。
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