Dual Inhibitor of SIRT2 Deacetylase and Defatty-Acylase Activities

Novel protease inhibitor (PI) against a variety of HIV-1 strains, including multi-PI-resistant strains, and may be less likely to generate resistance, also showing antiviral avtivity as a potential treatment for COVID-19 caused by SARS-CoV-2

Penem beta-lactam antibiotic

Novel inhibitor of plasminogen activator inhibitor-1 (PAI-1)

Novel inhibitor of both JAK/STAT and proteasome activities, inducing cell death in myeloma cells

Potent histone methyltransferase inhibitor with rapid antimalarial activity against all blood stage forms in Plasmodium falciparum

The first small molecule inhibitor of translesion synthesis (TLS) that target Rev1-CT

Novel toll-like receptor 8 (TLR8) inhibitor, potently and selectively reducing TLR8-mediated signaling

Novel potent and selective dual TLR7/8 inhibitor

Novel Toll-Like Receptor 4 (TLR4) Inhibitor

Novel Insulin Receptor Modulator

The first small molecule degrader, inducing anaplastic lymphoma kinase (ALK) degradation, including in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines

The first small molecule degrader, inducing anaplastic lymphoma kinase (ALK) degradation, including in non-small-cell lung cancer (NSCLC), anaplastic large-cell lymphoma (ALCL), and neuroblastoma (NB) cell lines

Novel AC220-based FLT3 degrader

Novel AC220-based FLT3 degrader

Anti-arrhythmia agent

hPPAR-pan agonist

Dual PPA

hPPAR

Novel hepcidin antagonist

Neurotoxin, acting via vanilloid receptors of sensory nerves

Novel pan-histone-deacetylase inhibitor with alkylating activity

Antiviral, antineoplastic, and anti-inflammatory agent; Orally active interferon inducer, inhibiting Ebola virus (EBOV)

Macrolide antibiotic for the treatment of bovine respiratory disease and ovine respiratory disease associated with Mannheimia (Pasteurella) haemolytica

Widely used oxidation-reduction indicator

Natural anticancer agent fortreatment of mast cell tumor (MCT)

Muscarinic receptor antagonist, anticholinergic,and parasympatholytic

Anthraquinone-fused enediyne antitumor agent for development of antibody-drug conjugates (ADCs)

Anti-epileptic and anticonvulsant agent, acting as a selective GABA reuptake inhibitor

Novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor