Novel Peripheral Selective Tryptophan Hydroxylase 1 (TPH1) Inhibitor (IC 50 : 42nM) for Obesity and Fatty Liver Disease

First-in-class fluorescent drug delivery vesicle that can efficiently load both water-soluble and -insoluble anticancer drugs

Novel probe for CECR2/BPTF bromodomains

Novel inhibitor of O-GlcNAcase (OGA)

Novel probe for activin receptor-like kinase (ALK4 and ALK5)

Novel ToxT inhibitor, reducing Vibrio cholerae virulence in vivo and effectively inhibiting intestinal colonization in the infant mouse

Selective CA IX inhibitor

Chromogenic peptide substrate for the rapid and specific photometric assay of recombinant hirudin (r-hirudin)

Natural psychoactive agent

Nucleic acid stain, acting on viable, early apoptotic and necrotic cells differentially, showing specific staining of nuclei without any staining of the cytoplasm

Novel highly specific fluorescent TOPK inhibitor

Novel Selective Inhibitor of Endoplasmic Reticulum α-Glucosidase II, Exhibiting Antiflaviviral Activity

Novel narrow spectrum kinase inhibitor, potently inhibiting P38a, Src, and Syk kinase activities

Novel dual TOP1 and TDP1 inhibitor, inducing both cellular TOP1cc, TDP1cc formation and DNA damage, resulting in cancer cell apoptosis at a sub-micromolar concentration

Natural agonist of TPRC1/4/5 channels, also acting as a dual PKCα and PKCθ activator, inducing an insulin resistant phenotype by inhibiting IRS1 and the PI3K/Akt pathway, activating the heat shock factor 1 (HSF1) transcription factor driving glucose depen

Stimulator of metabolism, preventing diseases associated with parturition and peri-partum period, developmental and nutritional disorders in young animals, and bone growth disorders and tetany or paresis caused by calcium, magnesium, and phosphorus metabo

Novel Human Toll-like Receptor 8-Selective Agonist

Unique multitargeting drug conjugate with extremely low propensity for development of resistance, targeting RNA polymerase, DNA gyrase, and DNA topoisomerase IV

Novel potent and selective tankyrase (TNKS) inhibitor

Highly potent and selective tankyrase inhibitor

Novel highly potent and selective TNKS2 inhibitor with antiproliferative effects in a colorectal cancer cell line (DLD-1) where the Wnt pathway is constitutively activated

Novel selective inhibitor of TNKS-USP25 interaction, effectively reducing prostate cancer cell proliferation and tumor growth

Novel non-nucleoside reverse transcriptase inhibitor of HIV-1

Emivirine analog with improved activity against drug-resistant HIV mutants

Novel inhibitor of tumor necrosis factor-α (TNF-α)

Novel potent inhibitor of TNF-α

Novel activator of necrostatin-1 sensitive necroptotic cell death, triggering apoptosis, autophagy and necroptosis crosstalk in chronic myeloid leukemia

Allosteric agonist and positive allosteric modulator (PAM) of 5-HT3 receptor

Novel caged protein labeling agent

Novel degrader of E. coli DHFR (eDHFR), as well as eDHFR-EGFP fusion proteins, demonstrating that degradation does not require covalent attachment of the tag to the target protein