Novel potent and broad-spectrum antiviral agent against multiple strains of EV-D68, EV-A71, and CVB3, targeting the viral protein 2C

Novel potent inhibitor of microtubule polymerization, binding directly to tubulin α/β heterodimers via the colchicine-binding site, perturbing mitotic spindles, delaying cells in mitosis and promotes apoptosis

Potent and selective dopamine D4 receptor antagonist

Novel competitive inhibitor of tyrosinase enzyme

Stable analog of phosphotyrosine (pTyr)

First-in-class selective PRMT5 inhibitor, blocking EBV-driven B lymphocyte transformation and survival while leaving normal B cells unaffected

Novel highly potent and selective TYK2 JH2 inhibitor, providing robust inhibition in a mouse IL-12-induced IFNγ pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model

Chymase inhibitor, preventing the development and progression of non-alcoholic steatohepatitis, improving vascular dysfunction and survival in stroke-prone spontaneously hypertensive rats

Novel disruptor of the bacterial protein, FtsZ

Novel anticancer agent, affecting steroid biosynthesis, increasing RagD expression, and causing abnormal cellular cholesterol localization

Natural potent porcine pancreatic elastase (PPE) inhibitor

Inhibitor of bacterial biofilm formation in Staphylococcus epidermidis

Novel Inhibitor of Metastatic Cancer Cell Migration and Invasion

Long-acting beta2-adrenergic receptor agonist

Novel allosteric modulator of free fatty acid receptor 3 (FFA3, previously GPR41)

Novel allosteric modulator of free fatty acid receptor 3 (FFA3, previously GPR41)

Novel potent tubulin polymerization inhibitor, forming stable interactions in the colchicine-binding site of tubulin, showing significant antiproliferative activities on a panel of tumor cell lines

Novel inhibitor of tubulin polymerization and caused HepG2 cells arrest in G2/M phase

LpxC substrate-analog inhibitor

FLT3 Kinase Inhibitor, Overcoming Both Activating and Drug Resistance Mutations in FLT3 in Acute Myeloid Leukemia

Novel transthyretin (TTR) stabilizer, binding to the T4 binding pocket of TTR and preventing the dissociation of TTR to monomer

First-in-class potent threonine tyrosine kinase (TTK) PROTAC, demonstrating strong TTK degradation in COLO-205 human colorectal cancer cells with DC 50 values of 3.1 nM

First-in-class potent threonine tyrosine kinase (TTK) PROTAC, demonstrating strong TTK degradation in COLO-205 human colorectal cancer cells with DC 50 values of 1.7 nM

Novel antagonist of T-type calcium channels

Novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo

Novel isoform-selective inhibitor of the tumor-associated hCA IX and XII

Novel human thymic stromal lymphopoietin (TSLP) inhibitor

Novel highly selective negative allosteric modulator (NAM) of thyrotropin receptor (TSHR), binding at the ectodomain/TMD interface, between the converging helix, ECL1 and the IA, noncompetitively inhibiting PAM-C2-activation

Natural Polycyclic Peptide from a Fungus-Derived Streptomycete

Natural DNA gyrase inhibitor, blocking leukotriene production, inhibiting P-glycoprotein, and showing anti-inflammatory and anti cancer activities