Novel agonist of the transient receptor potential melastatin 8 (TRPM8) ion channel

Novel selective inhibitor of the transient receptor potential melastatin 2 (TRPM2) channel, exhibiting TRPM2 selectivity over TRPM8 and TRPV1 channels as well as phospholipase A2 and showing neuroprotective activity in vitro, and significantly reducing ce

Novel potent and selective TRPA1 inhibitor, interacting with the N-terminal ankyrin repeat (ankyrinR) domain

Novel potent and selective TRPA1 inhibitor, interacting with the N-terminal ankyrin repeat (ankyrinR) domain

Novel potent and selective TRPA1 inhibitor, interacting with the N-terminal ankyrin repeat (ankyrinR) domain

Novel Photosensitive and Photoswitchable TRPA1 Agonist, Optically Control Pain through Channel Desensitization

Fluroquinolone antibiotic, suppressing c-Myc transcription and myeloma growth, inhibiting pannexin-1 channels through which ATP is released as find-me signals in apoptotic Jurkat cells

Serotonin 5-HT3 receptor antagonist

Potent and selective 5-HT3 receptor antagonist

First-in-class highly potent and selective inhibitor of TrmD (bacterial t-RNA-(N1G37) methyltransferase)

Novel potent and selective inhibitor of Tropomyosin-related kinase A (TrkA)

Novel opioid ligand for treatment of overactive bladder, acting as a μ-opioid receptor partial agonist

First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitor that Overcome Clinically Acquired Resistance

Novel anti-secretory and antiulcer agent for treatment of peptic ulcer disease and hypersecretory disorders

Copper ion chelator, causing the triple response phenotype by affecting copper ion transport in ethylene signaling from ATX1 to RAN1

Specific inhibitor of the histone H3 lysine 9 demethylase KDM4 in HeLa cells.

Antipsychotic and sedative agent as a potent antagonist of H1, 5-HT2A, and alpha1-adrenergic receptors

Metabolite of nicotinamide; Specific and potent inhibitor of NNMT, increasing histone methylation at H3K4 and methylated H3K4 occupancy at gene promoters

Novel Bromodomain Binding Mimic of Lysine Acetylation

Metabolite of Trifluoperazine; Antidepressant and antipsychotic

Potent NAE-hydrolyzing acid amidase (NAAA) inhibitor

AKT Inhibitor, Enhancing Gemcitabine Activity in Pancreatic Cancer Cells

EC 3.1.1.7 (Acetylcholinesterase) inhibitor, acting as an insecticide, an acaricide, an agrochemical, and a nematicide

Potent and long-acting derivative of the hormone Trenbolone

Central sugar signal in plants, regulating sucrose use and allocation, underpinning crop growth and development

Novel TGR5 agonist, reducing glycemic and dyslipidemic cardiovascular risk in animal models of diabesity

Inhibitor of histone deacetylases

Novel Highly Selective β2-Adrenoceptor Agonist as an Oral Antiasthmatic Agent

Metabolite of Resveratrol

Metabolite of Resveratrol