Cell-permeable antagonist of secreted frizzled related protein-1(sFRP-1), inhibiting Wnt-3/frizzled interaction and restoring cellular response to Wnt-3 stimulation

Novel anticancer agent, arresting cell cycle in S-phase and causes DNA replication stress leading to the phosphorylation of H2AX into gamma-H2AX

Novel dual inhibitor of BRD4 and PI3K, inhibiting BRD4, PI3Kα, PI3Kδ, and PI3Kγ with IC 50 values of 277, 714, 27, and 1170 nM, respectively

Potent, selective, and highly brain-penetrant NPY Y2 receptor antagonist

Potent and selective STAT5 inhibitor

The First potent SecA inhibitor

Novel telomerase inhibitor

Novel potent CYP17 lyase inhibitor, inhibiting androgen production without mineralocorticoid excess or cortisol depletion

Novel inhibitor of Mycobacterium marinum MelF (Rv1936), exhibiting bacteriostatic/bactericidal activity against M. marinum and M. tuberculosis in vitro

The most potent inhibitor of Set7, inhibiting the KMTase G9a

The first-in-class triple-site aaRS inhibitor, targeting Salmonella enterica threonyl-tRNA synthetase (SeThrRS) with IC 50 = 19 nM and K d = 35.4 nM

Highly selective H1 receptor antagonist

Cytochrome P450 14α-demethylase inhibitor, also acting as a BuChE-IDO1 inhibitor

Novel serotonin reuptake inhibitor

Novel mitochondrial KIM-1 receptor modulator to be specifically internalized by renal tubular epithelial cells via KIM-1 receptor-mediated endocytosis and then actively distributed in mitochondria under the effect of TPP, effectively ameliorating injured

Selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A) that prolong the benefit of eIF2α phosphorylation, thereby protecting cells from proteostatic defects

Novel selenium-nonsteroidal anti-inflammatory drug (Se-NSAID), inhibiting colorectal cancer (CRC) growth via the inhibition of the cell cycle in G1 and G2/M phases and reduces the cell cycle markers like cyclin E1 and B1 in a dose dependent manner

Sentrin-specific protease 1 (SENP1) inhibitor

Novel potent antagonist of the Hedgehog pathway

Novel Wnt inhibitor/Axin stabilizer

Novel S100B inhibitor

Novel AkaLumine analog, acting asa NIR emission luciferin with the enhanced solubility in water

Novel potent inhibitor of the enzyme soluble epoxide hydrolase (sEH)

Novel Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer's Disease

Antagonist of gamma-aminobutyric acid A (GABA A ) receptor and cholinergic agent

Novel open-ring metabolite of rapamycin derivative

Natural plant growth inhibitor

Highly selective human tachykinin NK1 receptor antagonist

Potent antiproliferative agent, binding to the “colchicine binding site” on tubulin and inhibiting tubulin polymerization in vitro

Novel inhibitor of sterol 14a-demethylases (CYP51)