Novel specific inhibitor of the ability of RegA to activate its target promoters, reducing expression of a number of proteins required for virulence

Novel inhibitor of the supercoiling and ATPase reactions of DNA gyrase, inhibiting gyrase by preventing the binding of ATP and showing selectivity against M. smegmatis.

Novel potent inhibitor of the supercoiling and ATPase reactions of DNA gyrase, inhibiting gyrase by preventing the binding of ATP

Novel Prenyltransferase Inhibitor with In Vitro and In Vivo Antibacterial Activity

Novel potent inhibitor of RECQL5-helicase activity, and stabilizing RECQL5-RAD51 physical interaction, leading to impaired HRR and preferential killing of RECQL5-expressing breast cancer

Novel HIV-1 Integrase Inhibitor

Novel HIV-1 Integrase Inhibitor

Novel Potent Broad-Spectrum Inhibitor of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp)

Novel highly potent, selective, and metabolically stable σ1 receptor agonist potentiating NGF-induced neurite outgrowth

Selective inhibitor of poly(ADP-Ribose) glycohydrolase (PARG)

Novel dual inhibitor of dihydroceramide desaturase (dhCerDS) and acid ceramidase (ACDase)

Novel dual inhibitor of dihydroceramide desaturase (dhCerDS) and acid ceramidase (ACDase)

Potent fluorescent α4β1/α9β1 inhibitor

Novel metabotropic glutamate type 5 (mGlu5) receptor negative allosteric modulator (NAM)

Novel inhibitor of geranylgeranyl diphosphate synthase (GGDPS)

Novel inhibitor of geranylgeranyl diphosphate synthase (GGDPS), showing significant reduction in tumor growth in mice

Novel potent inhibitor of p38 MAPK

Novel inhibitor of the tyrosine kinase BCR-ABL and platelet-derived growth factor receptor, inhibiting mitosis entry in acute myeloid leukemia cells via suppression of Aurora kinase A expression

Hsp90 N-terminal inhibitor

Potent anti-free radical agent, elevating glutathione peroxidase (GSH-PX) and super oxide dismutase (SOD) levels and lowering malonaldehyde (MDA) level in vivo in the Alzheimer's model

Novel potent selective androgen receptor modulator (SARM)

Inhibitor of Janus kinases

Novel potent DNA-alkylating agent, inhibiting TBP/DNA interaction

Prodrug of Racemetirosine, an inhibitor of tyrosine 3-monooxygenase

Novel inhibitor of PI3Kβ and PI3Kδ, inhibiting growth of PTEN deficient breast and prostate tumor

Potent and selective antagonist of 5-HT2A receptors

Efficient stabilizer of Mahoney procapsids

Novel Antiviral agent for Enterovirus D68

Novel inhibitor of HDL uptake induced by overexpression of scavenger receptor BI (SR-BI)

Novel scavenger receptor class B type I blocker