Novel reactivator of mutant p53, fuctioning as a zinc metallochaperone (ZMC) with diminished copper binding that functions as a chemotherapy and radiation sensitizer

Novel modulator of p53 activity, arresting at G2/M phase inducing delay of cell cycle progression

Selective spleen tyrosine kinase (SYK) inhibitor, suppressing leukocyte immune function and inflammation, and leading to a reduction in arthritis score and attenuated histological damage

Novel P2Y1 Antagonist

Second-generation active site-targeted covalent irreversible inhibitor of USP7

Novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein

Novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein

Novel INK4C inhibitor, specifically blocking the bioactivity of p18 protein

Novel p18(INK4C) inhibitor

δ-Opioid receptor agonist

Synthetic hormone with anabolic and androgenic properties

Antagonist of cell-surface heparan sulfate and heparin-protein interactions, reducing tau hyperphosphorylation and mitigating or delaying neuronal defects in tauopathies, including Alzheimer's disease

Vasodilator and β-adrenoreceptor agonist

Novel sulindac derivative; anti-inflammatory and anti-cancer agent

Novel inducer of differentiation in all six AML cell lines

Novel inhibitor of human cathepsin L

Novel inhibitor of the bromodomain and extra terminal domain (BET) bromodomain family member BRD4(1)

Novel potent inhibitor of GVIA iPLA2 with little or no inhibition against GIVA cPLA2 (XI(50) = 0.0073 and >0.91, respectively)

PPARalpha/gamma agonist

Novel dual inhibitor of the p53 interaction with MDM2 and MDMX

Potent inhibitor of PANC-1 cell migration and MYPT1 phosphorylation

Novel selective Ligand for the Orexin 2 Receptor (OX2R)

Brain penetrant, selective and high affinity OX1R antagonist

Novel anthelmintic agent

Novel anthelmintic agent, immobilising whipworm and reducing the ability of embryonated T. muris eggs to establish infection in the mouse host in vivo

First-in-class small molecule potentiator of cancer virotherapy, significantly enhancing virus replication-associated luciferase expression specifically in the tumor

Narural broad anticancer agent, upregulating hsa-miR-155, suppressing the BCR-ABL fusion gene and dysregulating the PI3K/AKT/mTOR pathway

Ovalbumin fragment peptide for study class II MHC-peptide binding and T-cell activation, binding to I-A(d) MHC class II protein, encompassing an allergenic and antigenic epitope of the ovalbumin protein

Ovalbumin fragment peptide as a class I (Kb)-restricted peptide epitope, triggering T cell activation in immunology studies

High affinity and human/rat species-selective histamine H3 receptor antagonist