Novel inverse agonist for the pancreatic-type ATP-sensitive K channel as vascular relaxing agent

First-in-class inhibitor of MFS efflux pump CaMdr1p

Novel selective inhibitor of the Polo-box domain of Polo-like kinase 1 (PLK1)

Specific and highly fluorescent substrate for caspase-1, also acting as a substrate for caspase-4

Novel neurotropic agent

Potent P-gp inhibitor with good selectivity towards BCRP pump (EC50 values 0.05 μM, 0.69 μM, 9.3 μM, and 73 μM for Caco-2, MDR1, MRP1, and BCRP inhibition, respectively)

Novel hybrid retinoid-HDAC inhibitor

Novel selective PARP1 inhibitor, inhibitng apoptosis and blocking poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells

The first inhibitor of forkhead Box Protein C2 (FOXC2)

Novel potent acetylcholinesterase (AChE) inhibitor

Potent and HDAC class I-selective inhibitor

Topical nonnucleoside reverse transcriptase inhibitor, partially preventing vaginal RT-SHIV infection of macaques

Novel specific inhibitor of HA-mediated viral entry, inhibiting HPAI H5N1 virus strain A/Hong Kong/H5N1

Antibacterial agent, with a relatively narrow spectrum against bacteria and a very high CC 50 value

Novel antibacterial agent, remarkably potent against antibiotic-resistant bacterial strains such as MDR A. baumannii , ESBL-producing Klebsiella pneumoniae, VRE, and MRSA

Potent antibacterial agent against a wide range of Gram-positive and Gram-negative bacteria

The first selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase

Deuterium-substituted anticancer agent, plinabulin, exhibiting better pharmacokinetic characteristics than that of plinabulin

Novel detergent, showing enhanced stability to all tested proteins compared to a gold standard detergent (DDM)

Novel detergent, showing enhanced stability to all tested proteins compared to a gold standard detergent (DDM)

Novel non-hemolytic and low toxic inhibitor of metallo-β-lactamases (MBLs), restoring the activity of meropenem against Escherichia coli, Citrobacter freundii, Proteus mirabilis and Klebsiella pneumonia, which carried resistance genes of blaNDM-1

Novel inhibitor of dengue and West Nile virus NS2B-NS3 protease

Novel Inhibitor of Mycobacterium tuberculosis α-1,4-Glucan Branching Enzyme (GlgB)

Prodrug of MB05032, acting as potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes

Novel potent inhibitor of the membrane-bound retinoid isomerase RPE65

Natural Anti-inflammation Agent, Attenuating Amyloid Plaques by Inducing Humoral Immune Response with Th2 Skewed Cytokine Response in the Tg (APPswe, PS1dE9) Alzheimer's Mouse Model

Novel potent inhibitor of May1 with Ki = 12 ± 1 nM, also inhibiting wild-type HIV-1 protease with Ki = 32 ± 5 pM and three drug resistance-associated mutants with Ki values ranging from 24 to 320 pM

Novel potent tyrosinase inhibitor from the Gram-negative bacterium Massilia albidiflava DSM 17472T

Novel, active, and less toxic anti-tuberculosis (anti-TB) agent

Inhibitor of voltage-gated K(+) (Kv) channels Kv1.3 and Kv1.5