Novel Aurora Kinase A Inhibitor

Novel dual inhibitor of GSK-3β and aurora kinase A, increasing somatic cell plasticity and inhibiting tumorigenicity

Novel potent and selective covalent inhibitor of EGFR and Her2 exon20 insertion mutations, exhibiting selectivity over wild type EGFR and within the kinome

Novel potent inhibitor of the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL) and dampening flux through the pentose phosphate pathway

Novel potent and selective covalent inhibitor of EGFR and Her2 exon20 insertion mutations, exhibiting selectivity over wild type EGFR and within the kinome

Novel potent and selective RON receptor tyrosine kinase inhibitor

Novel clickable linker for estrogen receptor degraders

Novel potent angiogenesis inhibitor, inhibiting VEGFR-2 and JAK/STAT3 signalling in primary cultured human endothelial cells and cancer cells

Novel activator of Lecithin:cholesterol acyltransferase (LCAT) including some familial mutations, by forming a hydrophobic adduct with Cys31

Novel antibiofilm coating, covalently bindng to a titanium implant surface (LC0024-Ti)

Neurotoxic amino acid

Prodrug of LB30870 as potent, orally active, selective and direct thrombin inhibitor

Potent, orally active, selective and direct thrombin inhibitor

Natural inhibitor of the proliferation of sensitive and resistant human cancer cell lines and this inhibitory activity is strongly increased in the presence of laxaphycin A

Natural antifungal and cytotoxic agent

Microtubule stabilzer, potently inhibiting cellular proliferation in cancer cell lines

Disruptor of microfilament-mediated processes

Natural F508del-CFTR trafficking corrector, targeting poly(ADP-ribose) polymerase (PARP)

Natural F508del-CFTR corrector, inhibiting both PARP-3 and -16, regulating the activity of the unfolded protein response activator inositol-requiring enzyme (IRE-1) via modulation of the level of its ribosylation by PARP-16

Novel Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitor

Novel orally active IKK2 inhibitor

Novel IKK-β inhibitor, reducing the secretion of TNF-α, IL-1β, IL-6, IL-12, IFN-γ and increased secretion of IL-10, protecting gastrointestinal homeostasis

Novel Adenosine A2a Receptor Agonist, Attenuating the Progression of Monocrotaline-induced Pulmonary Hypertension

Novel adenosine receptor agonist, inducing relaxation of corpus cavernosum; Novel selective phosphodiesterase-​4 (PDE4) inhibitor associated with anti-​TNF-​α properties

Novel dual TRPV1 antagonist and TNF-alpha production inhibitor

Lipopeptide antibiotic with activity against a range of Gram-positive bacteria including drug-resistant pathogens

Natural fungal phytotoxin, activating the plant jasmonic acid pathway

Novel, potent and selective CRTh2 antagonist

Potent inhibitor of histone deacetylase

Novel Modulator of autoimmune demyelination