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Novel inhibitors

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Cat. No. Product Name Field of Application Chemical Structure
DC49265 Propane-1,2,3-triyl tripalmitate-13C3-1
Propane-1,2,3-triyl tripalmitate-13C3-1 is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
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DC49264 Propane-1,2,3-triyl tripalmitate-13C3
Propane-1,2,3-triyl tripalmitate-13C3 is the 13C labeled Propane-1,2,3-triyl tripalmitate. Propane-1,2,3-triyl tripalmitate is an endogenous metabolite.
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DC49263 Phosphatidylinositol 4,5-bisphosphate
Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate), a phospholipid component of cell membranes, is a substrate for phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) and as a primary messenger.
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DC49262 6α-Hydroxy paclitaxel
6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion–transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer.
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DC49261 Fmoc-Lys(Pal-Glu-OtBu)-OH
Fmoc-Lys(Pal-Glu-OtBu)-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys(Pal-Glu-OtBu)-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49260 C18-PEG13-acid
C18-PEG13-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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DC49259 DYSP-C34
DYSP-C34 is a potent, biocompatible, and ultrasound (US)-triggered multifunctional molecular machine. DYSP-C34 has multiple favorable properties, such as improved lipophilic/hydrophilic balance, intensified US-induced ROS production capacity, and better cellular permeability, resulting in the excellent tumor target efficiency and notable sonodynamic therapy (SDT)-mediated tumor regression. DYSP-C34 exhibits mild immunogenicity by stimulating APCs directly.
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DC49258 Berninamycin D
Berninamycin D is a cyclic peptide fungal metabolite isolated from ermentation of Streptomyces bernensis.
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DC49256 Phytochelatin 5 TFA
Phytochelatin 5 TFA is metal-binding compound produced by plants. Phytochelatin 5 TFA may reduce bioavailability of dietary toxic metals such as cadmium.
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DC49254 Cyclotheonellazole A
Cyclotheonellazole A is a natural macrocyclic peptide and a potent elastase inhibitor (IC50=0.034 nM). Cyclotheonellazole A inhibits chymotrypsin with an IC50 value of 0.62 nM.
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DC49253 MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D
MethylCBI-azaindole-benzamide-MOM-Boc-ethylenediamine-D is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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DC49252 PROTAC ER Degrader-10
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research. PROTAC ER Degrader-10 is extracted from patent WO2021133886, example 36.
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DC49251 Cerebroside D
Cerebroside D, a glycoceramide compound, improves experimental colitis in mice with multiple targets against activated T lymphocytes.
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DC49250 CY5-SE triethylamine salt
Cy5-SE (Cy5 NHS Ester) triethylamine salt is a reactive dye for the labeling of amino-groups in peptides, proteins, and oligonucleotides. Cy5-SE triethylamine salt is ideal for very cost-efficient labeling of soluble proteins, as well as all kinds of peptides and oligonucleotides Ex=649 nm; Em=670 nm).
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DC49248 Phytochelatin 5
Phytochelatin 5 is metal-binding compound produced by plants. Phytochelatin 5 may reduce bioavailability of dietary toxic metals such as cadmium.
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DC49247 UNC6864 (Kei)
UNC6864 (Kei), an ethylisopropyllysine (Kei)-containing ligand, binds to wild-type CBX5, with a KD of 3.3 μM.
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DC49245 PROTAC BRD9 Degrader-4
PROTAC BRD9 Degrader-4 is a BRD9 bifunctional degrader for treating cancer.
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DC49244 Insecticidal agent 1
Insecticidal agent 1 displays more potent insecticidal activity than obacunone and toosendanin.
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DC49243 TF-3-G-cThea
TF-3-G-cThea is a storage-related marker compound in black tea.
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DC49242 HIV-1 inhibitor-11
HIV-1 inhibitor-11, a fused pyridine ring derivative, is a HIV-1 inhibitor. WO2021104413A1 ( compound 1-1b).
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DC49241 HIV-1 inhibitor-12
HIV-1 inhibitor-12 is potent HIV-1 inhibitor. HIV-1 inhibitor-12 inhibits HIV-1 capsid protein polymerization with an IC50 of 9 nM (WO2021104413A1, compound 1-1a).
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DC49240 Galloyl-bis-HHDP glucose
Galloyl-bis-HHDP glucose (HeT) is an ellagitannin, which exhibits phytoprotective effects against Pseudomonas viridiflava.
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DC49238 Dielaidoylphosphatidylethanolamine
Dielaidoylphosphatidylethanolamine is a liposome used to deliver drugs.
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DC49236 Cerebroside A
Cerebroside A is a single molecule cerebroside extracted and isolated from an edible mushroom. Cerebroside A provides potent neuroprotection after cerebral ischaemia through reducing glutamate release and Ca²⁺ influx of NMDA receptors.
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DC49235 p3Ysh-3
p3Ysh-3 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 1.09 μM. p3Ysh-3 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p3Ysh-3 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators.
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DC49234 UNC6349 (Ket2)
UNC6349 (Ket2), a diethyllysine (Ket2)-containing ligand, binds to wild-type CBX5, with a KD of 3.2 μM.
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DC49233 Coblopasvir dihydrochloride
Coblopasvir (KW-136) dihydrochloride is a pangenotypic non-structural protein 5A (NS5A) inhibitor. Coblopasvir dihydrochloride can be used for research of chronic hepatitis C virus infection.
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DC49232 PROTAC BRD9 Degrader-3
PROTAC BRD9 Degrader-3 is a BRD9 bifunctional degrader for treating cancer.
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DC49231 SJ10542
SJ10542 is a potent and selective JAK2/3 directing phenyl glutarimide (PG)-PROTAC with DC50s of 14, 11, and 24 nM for JAK2, JAK3, and JAK2-fusion ALL, respectively. SJ10542 utilizes a PG ligand as the cereblon (CRBN) recruiter.
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DC49230 TF-3ʹ-G-cThea
TF-3ʹ-G-cThea is a storage-related marker compound in black tea.
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